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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소아소화기영양학회 Pediatric Gastroenterology, Hepatology & Nutrition Pediatric Gastroenterology, Hepatology & Nutrition 제24권 제2호
- 발행연도
- 2021.1
- 수록면
- 187 - 196 (10page)
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Purpose: The rising prevalence of childhood obesity in the past decades has caused nonalcoholic fatty liver disease (NAFLD) to become the most common cause of pediatric chronic liver disease worldwide. This study was aimed at determining the effect of vitamin D (Vit D) on ultrasonography and laboratory indices of NAFLD and some blood biochemical indicators in children. Methods: In this interventional study liver ultrasonography was performed in 200 children with overweight and obesity. A 108 had fatty liver among which 101 were randomly divided into two groups of study (n=51) and control (n=50). The study group was treated with Vit D, 50000 U once a week whereas the control group received placebo with the same dose and package, both for 12 weeks. At the end of the intervention lab tests and ultrasound study was performed once again to evaluate the response to treatment. Results: It was found out that Vit D supplementation improved the fatty liver grade in the study group. The mean changes in hemoglobin (Hb), uric acid, highdensity lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), insulin, albumin and alanine aminotransferase (ALT) was significantly higher in the study group compared to controls (p<0.05). After the intervention and means adjustment, a significant difference was obtained in HDL-C, insulin, LDL-C and homeostasis model assessment of insulin resistance (HOMA-IR) between the two groups. Conclusion: Vit D supplementation in addition to improving the fatty liver grade in ultrasonography and increasing the blood Vit D level, increases the HDL and Hb level besides decreasing uric acid, LDL, HOMA-IR, insulin and ALT levels.
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참고문헌 (36)
참고문헌 신청
de Onis M / 2010 / Global prevalence and trends of overweight and obesity among preschool children / Am J Clin Nutr 92:1257~1264
Yildiz I / 2014 / Role of vitamin D in children with hepatosteatosis / J Pediatr Gastroenterol Nutr 59:106~111
Low S / 2009 / Review on epidemic of obesity / Ann Acad Med Singap 38:57~59
Malespin M / 2015 / Prevalence and correlates of suspected nonalcoholic fatty liver disease in Chinese American children / J Clin Gastroenterol 49:345~349
Burke A / 2004 / Non-alcoholic fatty liver disease, non-alcoholic steatohepatitis and orthotopic liver transplantation / Am J Transplant 4:686~693
Yildiz I / 2014 / Role of vitamin D in children with hepatosteatosis / J Pediatr Gastroenterol Nutr 59:106~111
Low S / 2009 / Review on epidemic of obesity / Ann Acad Med Singap 38:57~59
Malespin M / 2015 / Prevalence and correlates of suspected nonalcoholic fatty liver disease in Chinese American children / J Clin Gastroenterol 49:345~349
Burke A / 2004 / Non-alcoholic fatty liver disease, non-alcoholic steatohepatitis and orthotopic liver transplantation / Am J Transplant 4:686~693
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