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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 1 - 7 (7page)
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Abstract Introduction: Fatty liver is associated with metabolic syndrome (MetS) but it may also occur without MetS.
Whether resolution of fatty liver in the general population affects risk of MetS is unknown. Our aim was to determine whether a change in fatty liver status (either the development of new fatty liver or the resolution of existing fatty liver) would modify the risk of de novo MetS.
Methods: Two thousand eighty-nine people without hypertension, diabetes, and MetS were examined at baseline and at 5-year follow-up using a retrospective cohort study design. Fatty liver status was assessed at baseline and at follow-up by ultrasonography. Adjusted hazard ratios (aHR) and 95 % confidence intervals (CIs) for de novo MetS at follow-up were calculated controlling for the potential confounders, compared to the reference group (people who never had fatty liver at baseline and follow-up).
Results: During follow-up, fatty liver developed in 251 people and fatty liver resolved in 112 people. After the adjustment for multiple confounders, persisting fatty liver and incident fatty liver development were associated with de novo MetS, with aHR of 2.60 (95 % CIs [1.61,4.20]) and 3.31 (95 % CIs [1.99,5.51]), respectively. Risk of new MetS in resolved fatty liver group was attenuated with insignificant aHR of 1.29 accompanying 95 % CIs of 0.60 and 2.80.
Discussion: Development or maintenance of fatty liver is positively associated with occurrence of new MetS.
Resolution of fatty liver status has similar risk of de novo MetS with those who never had fatty liver. Therefore, cautious management is needed with those with fatty liver.
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참고문헌 (24)
참고문헌 신청
Ardigo D. / 2010 / The increase in plasma PAI-1 associated with insulin resistance may be mediated by the presence of hepatic steatosis / Atherosclerosis 208 : 240 ~ 245
Bedogni G. / 2005 / Prevalence of and risk factors for nonalcoholic fatty liver disease : the Dionysos nutrition and liver study / Hepatology 42 : 44 ~ 52
Browning JD. / 2004 / Prevalence of hepatic steatosis in an urban population in the United States : impact of ethnicity / Hepatology 40 : 1387 ~ 1395
Clark JM. / 2002 / Hepatic steatosis and type 2 diabetes mellitus / Curr Diab Rep 2 : 210 ~ 215
Eckel RH. / 2005 / The metabolic syndrome / Lancet 365 : 1415 ~ 1428
Bedogni G. / 2005 / Prevalence of and risk factors for nonalcoholic fatty liver disease : the Dionysos nutrition and liver study / Hepatology 42 : 44 ~ 52
Browning JD. / 2004 / Prevalence of hepatic steatosis in an urban population in the United States : impact of ethnicity / Hepatology 40 : 1387 ~ 1395
Clark JM. / 2002 / Hepatic steatosis and type 2 diabetes mellitus / Curr Diab Rep 2 : 210 ~ 215
Eckel RH. / 2005 / The metabolic syndrome / Lancet 365 : 1415 ~ 1428
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