지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 450 - 458 (9page)
이용수
초록· 키워드
오류제보하기
Objective A popular design for the investigation of such effects, including effects of parent-of-origin (imprinting), maternal genotype, and maternal-fetal genotype interactions, is to collect deoxyribonucleic acid (DNA) from affected offspring and their mothers and to compare with an appropriate control sample. We investigate the effects of estimation of maternal, imprinting and interaction effects using multimodal modeling using parents and their offspring with schizophrenia in Korean population. Methods We have recruited 27 probands (with schizophrenia) with their parents and siblings whenever possible. We analyzed 20 SNPs of 7 neuronal genes in chromosome 18. We used EMIM analysis program for the estimation of maternal, imprinting and interaction effects using multimodal modeling. Results Of analyzed 20 single nucleotide polymorphisms (SNPs), significant SNP (rs 2276186) was suggested in EMIM analysis for child genetics effects (p=0.0225438044) and child genetic effects allowing for maternal genetic effects (p=0.0209453210) with very stringent multiple comparison Bonferroni correction. Conclusion Our results are the pilot study for epigenetic study in mental disorder and help to understanding and use of EMIM statistical genetics analysis program with many limitations including small pedigree numbers.
목차
등록된 정보가 없습니다.
참고문헌 (81)
참고문헌 신청
McGuffin P / 1994 / The strength of the genetic effect. Is there room for an environmental influence in the aetiology of schizophrenia? / Br J Psychiatry 164:593~599
Bachmann RF / 2005 / Mood stabilizers target cellular plasticity and resilience cascades : implications for the development of novel therapeutics / Mol Neurobiol 32:173~202
Bartels SJ / 2003 / Medicare and medicaid costs for schizophrenia patients byage cohort compared with costs for depression, dementia, and medically ill patients / Am J Geriatr Psychiatry 11:648~657
Bauer M / 2002 / NIMH Affective Disorders Workgroup Bipolar disorder / Ment Health Serv Res 4:225~229
Shih RA / 2004 / A review of the evidence from family, twin and adoption studies for a genetic contribution to adult psychiatric disorders / Int Rev Psychiatry 16:260~283
Bachmann RF / 2005 / Mood stabilizers target cellular plasticity and resilience cascades : implications for the development of novel therapeutics / Mol Neurobiol 32:173~202
Bartels SJ / 2003 / Medicare and medicaid costs for schizophrenia patients byage cohort compared with costs for depression, dementia, and medically ill patients / Am J Geriatr Psychiatry 11:648~657
Bauer M / 2002 / NIMH Affective Disorders Workgroup Bipolar disorder / Ment Health Serv Res 4:225~229
Shih RA / 2004 / A review of the evidence from family, twin and adoption studies for a genetic contribution to adult psychiatric disorders / Int Rev Psychiatry 16:260~283
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