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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 389 - 396 (8page)
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초록· 키워드
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Interstitial lung disease (ILD) is a major cause of death in patients with dermatomyositis (DM). This study was aimed to examine the utility of the erythrocyte sedimentation rate (ESR) as a predictor of ILD and prognostic marker of mortality in patients with DM. One hundred-and-fourteen patients with DM were examined, including 28 with clinically amyopathic DM (CADM). A diagnosis of ILD was made based on high resolution computed tomography (HRCT) scans. The association between elevated ESR and pulmonary impairment and mortality was then examined. ILD was diagnosed in 53 (46.5%) of 114 DM patients. Cancer was diagnosed in 2 (3.8%) of 53 DM patients with ILD and in 24 (92.3%) of those without ILD (P < 0.001). The median ESR (50.0 mm/hour) in patients with ILD was significantly higher than that in patients without ILD (29.0 mm/hour; P < 0.001). ESR was inversely correlated with forced vital capacity (Spearman ρ = -0.303; P = 0.007) and carbon monoxide diffusing capacity (ρ = -0.319; P = 0.006). DM patients with baseline ESR ≥ 30 mm/hour had significantly higher mortality than those with ESR < 30 mm/hour (P = 0.002, log-rank test). Patients with a persistently high ESR despite immunosuppressive therapy was associated with higher mortality than those with a normalized ESR (P = 0.039, log-rank test). Elevated ESR is associated with increased mortality in patients with DM due to respiratory failure. Thus, monitoring ESR should be an integral part of the clinical care of DM patients.
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참고문헌 (8)
참고문헌 신청
Marie I / 1998 / Pulmonary involvement in polymyositis and in dermatomyositis / J Rheumatol 25:1336~1343
Marie I / 2002 / Interstitial lung disease in polymyositis and dermatomyositis / Arthritis Rheum 47:614~622
Fathi M / 2004 / Interstitial lung disease, a common manifestation of newly diagnosed polymyositis and dermatomyositis / Ann Rheum Dis 63:297~301
Sontheimer RD / 2002 / Would a new name hasten the acceptance of amyopathic dermatomyositis (dermatomyositis siné myositis) as a distinctive subset within the idiopathic inflammatory dermatomyopathies spectrum of clinical illness? / J Am Acad Dermatol 46:626~636
Gerami P / 2006 / A systematic review of adult-onset clinically amyopathic dermatomyositis(dermatomyositis siné myositis) : a missing link within the spectrum of the idiopathic inflammatory myopathies / J Am Acad Dermatol 54:597~613
Marie I / 2002 / Interstitial lung disease in polymyositis and dermatomyositis / Arthritis Rheum 47:614~622
Fathi M / 2004 / Interstitial lung disease, a common manifestation of newly diagnosed polymyositis and dermatomyositis / Ann Rheum Dis 63:297~301
Sontheimer RD / 2002 / Would a new name hasten the acceptance of amyopathic dermatomyositis (dermatomyositis siné myositis) as a distinctive subset within the idiopathic inflammatory dermatomyopathies spectrum of clinical illness? / J Am Acad Dermatol 46:626~636
Gerami P / 2006 / A systematic review of adult-onset clinically amyopathic dermatomyositis(dermatomyositis siné myositis) : a missing link within the spectrum of the idiopathic inflammatory myopathies / J Am Acad Dermatol 54:597~613
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