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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.7
- 수록면
- 172 - 172 (1page)
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The generation of autologous monocyte progenitor cells (MPCs) can offer therapeutic benefits in animal model of various inflammatory diseases, such as inflammatory bowel disease (IBD). Although MPCs can be differentiated from induced pluripotent stem cells (iPSCs), their applications are limited for the clinical applications due to the tumorigenicity in vivo. To avoid the risk of the tumorigenicity, direct conversion method has emerged as advanced reprogramming technology. Here, we demonstrate that fibroblasts can be converted into induced myeloid progenitor cells (iMPCs) by induction of one transcription factor. Our method enables the large production of highly pure self-renewing iMPCs expressing monocytic lineage markers (CD34, CD45). iMPCs exhibit the hallmarks of bona fide monocyte progenitor cells, including cell ... 전체 초록 보기
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