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Current and Future Perspectives of Stem Cell Therapy in Dermatology
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논문 기본 정보

Type
Academic journal
Author
Journal
Korean Dermatological Association Annals of Dermatology Annals of Dermatology 제29권 제6호 KCI Accredited Journals SCOPUS
Published
2017.1
Pages
667 - 687 (21page)

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Current and Future Perspectives of Stem Cell Therapy in Dermatology
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Abstract· Keywords

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Stem cells are undifferentiated cells capable of generating, sustaining, and replacing terminally differentiated cells and tissues. They can be isolated from embryonic as well as almost all adult tissues including skin, but are also generated through genetic reprogramming of differentiated cells. Preclinical and clinical research has recently tremendously improved stem cell therapy, being a promising treatment option for various diseases in which current medical therapies fail to cure, prevent progression or relieve symptoms. With the main goal of regeneration or sustained genetic correction of damaged tissue, advanced tissue-engineering techniques are especially applicable for many dermatological diseases including wound healing, genodermatoses (like the severe blistering disorder epidermolysis bullosa) and chronic (auto-)inflammatory diseases. This review summarizes general aspects as well as current and future perspectives of stem cell therapy in dermatology.
#Epidermal stem cells #Epidermolysis bullosa #Induced pluripotent stem cells #Mesenchymal multipotent stromal cells #Stem cell therapy #Wound healing

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References (29)

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Barrandon Y / 1987 / Three clonal types of keratinocyte with different capacities for multiplication / Proc Natl Acad Sci U S A 84 : 2302 ~ 2306 google schola Beaver CM / 2014 / Clonogenicity: holoclones and meroclones contain stem cells / PLoS One 9 : e89834 ~ google schola Bilousova G / 2014 / Induced pluripotent stem cells in dermatology: potentials, advances, and limitations / Cold Spring Harb Perspect Med 4 : a015164 ~ google schola Blanpain C / 2004 / Self-renewal, multipotency, and the existence of two cell populations within an epithelial stem cell niche / Cell 118 : 635 ~ 648 google schola Blanpain C / 2006 / Epidermal stem cells of the skin / Annu Rev Cell Dev Biol 22 : 339 ~ 373 google schola

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