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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 190 - 195 (6page)
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Induced pluripotent stem cells (iPSC) are specially manipulated cells from somatic cells by the introduction of four factors that are reprogrammed. The properties of iPSC are similar to embryonic stem cells (ESC) characteristic of self-renewal and pluripotency. The technology of reprogramming somatic cells to iPSC enables the generation of patient-specific cells that can be used as powerful tools for drug screening, in vitro models for human disease and autologous transplantation. The iPSC technology provides a priceless resource for regenerative medicine but there are still changing obstacles over the safety of iPSC in avoiding induction of tumorigenicity and maintaining high purity of re-differentiated cells from iPSC to produce more functional cells for cell therapy. A variety of methods to overcome the limitation of iPSC application applied in the clinical setting have been developed. In this review, we summarize the recent progress in iPSC generation and differentiation techniques to facilitate clinical application of iPSC with future potential in regenerative medicine.
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참고문헌 (49)
참고문헌 신청
Keating A. / 2012 / Mesenchymal stromal cells: new directions / Cell Stem Cell 10:709~716
Svendsen CN. / 2013 / Back to the future: how human induced pluripotent stem cells will transform regenerative medicine / Hum Mol Genet 22:R32~R38
Chen KG / 2014 / Human pluripotent stem cell culture: considerations for maintenance, expansion, and therapeutics / Cell Stem Cell 14:13~26
Takahashi K / 2006 / Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors / Cell 126:663~676
Takahashi K / 2007 / Induction of pluripotent stem cells from adult human fibroblasts by defined factors / Cell 131:861~872
Svendsen CN. / 2013 / Back to the future: how human induced pluripotent stem cells will transform regenerative medicine / Hum Mol Genet 22:R32~R38
Chen KG / 2014 / Human pluripotent stem cell culture: considerations for maintenance, expansion, and therapeutics / Cell Stem Cell 14:13~26
Takahashi K / 2006 / Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors / Cell 126:663~676
Takahashi K / 2007 / Induction of pluripotent stem cells from adult human fibroblasts by defined factors / Cell 131:861~872
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Progress and emerging techniques for biomaterial-based derivation of mesenchymal stem cells (MSCs) from pluripotent stem cells (PSCs)
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The study for role of Jazf1 in pathogenesis of diabetes utilizing transgenic mice and induced pluripotent stem cells
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Heterogeneity of Islet Cells during Embryogenesis and Differentiation
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Current and Future Perspectives of Stem Cell Therapy in Dermatology
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Prediction of diabetes mellitus after kidney transplantation using patient-specific induced pluripotent stem cells
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Highly efficient human hematopoietic stem and progenitor cell generation from induced pluripotent stem cells using a simple scalable monolayer culture system
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