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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Preventive Nutrition and Food Science Preventive Nutrition and Food Science Vol.26 No.2
- 발행연도
- 2021.6
- 수록면
- 177 - 185 (9page)
이용수
초록· 키워드
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Dennettia tripetala, better known as ‘pepperfruit’, is a medicinal plant consumed in West Africa. D. tripetala possesses strong antioxidant properties and contains uvariopsine, an alkaloid which improves bile secretion and liver function. In the present study, the ethanolic extract of D. tripetala fruits was tested for its ability to alleviate pathophysiological conditions bordering on oxidative stress, including protein and lipid dyshomeostasis, inflammation, and hepatic and glomerular injury. Male albino Wistar rats were administered carbon tetrachloride twice a week for two weeks, and the ethanolic extract of D. tripetala fruits was administered from days 8∼14. The serum, liver, and kidneys of the rats were then subjected to biochemical assays and imaging. The extract restored the activities of liver marker enzymes in serum and the concentrations of lipids and proteins in both circulation and the liver to normal. The extract also restored the activities of antioxidant enzymes in liver and kidneys, and the concentrations of urea and creatinine in the blood. The extract also repaired the altered structures of the liver and kidney. Overall, D. tripetala elicited strong medicinal effects in rats. This study showed that the fruits of D. tripetala contain substances that could be extracted or synthesized for use in drugs for the treatment of liver and kidney disease.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (29)
참고문헌 신청
Mohammed Al-Yahya / 2013 / Attenuation of CCl4-Induced Oxidative Stress and Hepatonephrotoxicity by Saudi Sidr Honey in Rats / Evidence-Based Complementary and Alternative Medicine 2013:1~10
Innocent Anioke / 2017 / Investigation into Hypoglycemic, Antihyperlipidemic, and Renoprotective Potentials ofDennettia tripetala(Pepper Fruit) Seed in a Rat Model of Diabetes / BioMed Research International 2017:1~11
Boll M / 2001 / Hepatocyte damage induced by carbon tetrachloride : inhibited lipoprotein secretion and changed lipoprotein composition / Z Naturforsch C J Biosci 56:283~290
Bright E / 2017 / The effect of ethanol extract of Dennettia tripetala(pepper fruit)on gastric acid secretion in Wistar rats / Res Rev J Med Health Sci 6:21~26
Buege JA / 1978 / Microsomal lipid peroxidation / Methods Enzymol 52:302~310
Innocent Anioke / 2017 / Investigation into Hypoglycemic, Antihyperlipidemic, and Renoprotective Potentials ofDennettia tripetala(Pepper Fruit) Seed in a Rat Model of Diabetes / BioMed Research International 2017:1~11
Boll M / 2001 / Hepatocyte damage induced by carbon tetrachloride : inhibited lipoprotein secretion and changed lipoprotein composition / Z Naturforsch C J Biosci 56:283~290
Bright E / 2017 / The effect of ethanol extract of Dennettia tripetala(pepper fruit)on gastric acid secretion in Wistar rats / Res Rev J Med Health Sci 6:21~26
Buege JA / 1978 / Microsomal lipid peroxidation / Methods Enzymol 52:302~310
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