Mitigating Effect of Resveratrol on the Structural Changes of Mice Liver and Kidney Induced by Cadmium : A Stereological Study :A Stereological Study

Ali Rafati; Leila Hoseini; Ali Babai; Ali Noorafshan; Hossein Haghbin; Saied Karbalay-Doust

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자료유형: 학술저널

저자정보: Ali Rafati (Shiraz University of Medical Sciences) Leila Hoseini (Shiraz University of Medical Sciences) Ali Babai (Shiraz University of Medical Sciences) Ali Noorafshan (Shiraz University of Medical Sciences) Hossein Haghbin (Shiraz University of Medical Sciences) Saied Karbalay-Doust (Shiraz University of Medical Sciences)

저널정보: 한국식품영양과학회 Preventive Nutrition and Food Science Preventive Nutrition and Food Science Vol.20 No.4

발행연도: 2015.12

수록면: 266 - 275 (10page)

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Exposure to cadmium (Cd) has harmful effects on the liver and kidney. Resveratrol (RES) is an herbal substance that functions as a protective mediator. This study aimed to investigate the effects of RES on the histology of liver and kidney in Cd-exposed mice. Male mice were divided into 4 groups daily receiving normal saline (1 mL normal saline/d), Cd (1 mg/kg/d), RES (20 mg/kg/d), and Cd plus RES, respectively. After 4 weeks, the liver and kidney components were evaluated using stereological methods. The total volume and number of hepatocytes, and volume of fibrous tissue were respectively increased by 34%, 58%, and a 3-fold in the Cd-exposed mice in comparison to the control animals (P＜0.03). On the other hand, the volume of the main vasculature (sinusoids and central veins) was decreased by 36% in the Cd group compared to the control mice (P＜0.03). Considering the kidney, the results showed a 3-fold increase in the total glomeruli volume and a 7-fold increase in fibrous tissue in the Cd-treated group compared to the control mice (P＜0.03). After Cd treatment, a 32% reduction was observed in the volume and length of the proximal and distal convoluted tubules. RES-treatment alone did not induce any structural changes. In comparison to the Cd group, an increase in the normal components of the liver and kidney and a decrease in the formation of the fibrous and degenerated tissues were observed in the Cd+RES-treated mice (P＜0.03).

#cadmium #resveratrol #liver #kidney #quantitative

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