지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.6
- 수록면
- 201 - 209 (9page)
- DOI
- 10.7783/KJMCS.2021.29.3.201
이용수
초록· 키워드
오류제보하기
Background: This study has been carried out to investigate the protective effect of Korean Red Ginseng Non-Saponin Fraction (RGNSF) on clinical chemical parameters in male rats acutely exposed to 2,3,7,8-tetrachlorodibenzo-ρ-dioxin (TCDD).
Methods and Results: RGNSF was prepared from red ginseng residues after ethanol extraction of red ginseng. The RGNSF was characterized by the saponin and free sugars of TLC. RGNSF did not contain saponin compounds and consisted of several sugars such as glucose, galactose, and sucrose. To investigate the protective effect of RGNSF on TCDD, forty male rats (Sprague Dawley, 180 ± 20 g) were divided into 4 groups. The normal control group (NC) received the vehicle (i.p.) and saline (p.o.) daily. The only TCDD treated group (TT) received a single dose of TCDD (40 ㎍/㎏, i.p.) and saline. The RGNSF receiving groups were administered p.o. at a daily dose of 100 ㎎/㎏ (RGNSF100) and 200 ㎎/㎏ (RGNSF200) for 3 weeks beginning a week before TCDD exposure. Body-weight gain of TT and RGNSF100 were inhibited after TCDD exposure. The body-weight of RGNSF200 was increased throughout the experimental period, although the increasing rate was slower than that of NC. A decrease in testis weights for the male rats due to TCDD exposure was significantly observed in the RGNSF200 group. Body-weight gain inhibition and the recovery of testis weight by RGNSF administration were dose dependent. Increases in WBC, RBC, hemoglobin, and hematocrit by TCDD intoxication were attenuated by RGNSF administration but were not significant. Increasing AST toxicity by TCDD was significantly inhibited by RGNSF administration with a dose-dependent manner.
Conclusions: These results suggest that RGNSF might be a useful protective agent against TCDD, an endocrine disruptor.
Methods and Results: RGNSF was prepared from red ginseng residues after ethanol extraction of red ginseng. The RGNSF was characterized by the saponin and free sugars of TLC. RGNSF did not contain saponin compounds and consisted of several sugars such as glucose, galactose, and sucrose. To investigate the protective effect of RGNSF on TCDD, forty male rats (Sprague Dawley, 180 ± 20 g) were divided into 4 groups. The normal control group (NC) received the vehicle (i.p.) and saline (p.o.) daily. The only TCDD treated group (TT) received a single dose of TCDD (40 ㎍/㎏, i.p.) and saline. The RGNSF receiving groups were administered p.o. at a daily dose of 100 ㎎/㎏ (RGNSF100) and 200 ㎎/㎏ (RGNSF200) for 3 weeks beginning a week before TCDD exposure. Body-weight gain of TT and RGNSF100 were inhibited after TCDD exposure. The body-weight of RGNSF200 was increased throughout the experimental period, although the increasing rate was slower than that of NC. A decrease in testis weights for the male rats due to TCDD exposure was significantly observed in the RGNSF200 group. Body-weight gain inhibition and the recovery of testis weight by RGNSF administration were dose dependent. Increases in WBC, RBC, hemoglobin, and hematocrit by TCDD intoxication were attenuated by RGNSF administration but were not significant. Increasing AST toxicity by TCDD was significantly inhibited by RGNSF administration with a dose-dependent manner.
Conclusions: These results suggest that RGNSF might be a useful protective agent against TCDD, an endocrine disruptor.
목차
ABSTRACT
서언
재료 및 방법
결과 및 고찰
REFERENCES
참고문헌 (34)
참고문헌 신청
Ann YG / 1997 / Sugars in Korean ginseng(Panax ginseng C. A Meyer) / Korean Journal Food and Nutrition 10:480~484
Bertazzi PA / 1998 / The seveso studies on early and long-term effects of dioxin exposure : A review / Environmental Health Perspectives 106:625~633
Bombick DW / 1984 / TCDD(2, 3, 7, 8-tetrachlorodibenzo-p-dioxin)causes reduction in the low density lipoprotein(LDL)receptor activities in the hepatic plasma membrane of the guinea pig and rat / Biochemical and Biophysical Research Communications 118:548~554
Brewster DW / 1989 / Differential effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on adipose tissue lipoprotein lipase activity in the guinea pig, rat, hamster, rabbit and mink / Comparative Biochemistry and Physiology. Part C. Comparative Pharmacology 93:49~53
Byeon SE / 2012 / Molecular mechanism of macrophage activation by red ginseng acidic polysaccharide from Korean red ginseng / Mediators of Inflammation :732860
Bertazzi PA / 1998 / The seveso studies on early and long-term effects of dioxin exposure : A review / Environmental Health Perspectives 106:625~633
Bombick DW / 1984 / TCDD(2, 3, 7, 8-tetrachlorodibenzo-p-dioxin)causes reduction in the low density lipoprotein(LDL)receptor activities in the hepatic plasma membrane of the guinea pig and rat / Biochemical and Biophysical Research Communications 118:548~554
Brewster DW / 1989 / Differential effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on adipose tissue lipoprotein lipase activity in the guinea pig, rat, hamster, rabbit and mink / Comparative Biochemistry and Physiology. Part C. Comparative Pharmacology 93:49~53
Byeon SE / 2012 / Molecular mechanism of macrophage activation by red ginseng acidic polysaccharide from Korean red ginseng / Mediators of Inflammation :732860
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