지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.4
- 수록면
- 135 - 143 (9page)
- DOI
- 10.7783/KJMCS.2021.29.2.135
이용수
초록· 키워드
오류제보하기
Background: The effects of Panax ginseng C. A. Meyer in protecting and promoting the differentiation of muscle cells have been reported. However, the influences of various ginseng species and various fractions were not investigated.
Methods and Results: In this study, these effects on muscle cells were confirmed using butanol and water fractions of various ginseng species. The fractions of P. ginseng were confirmed to have a cytoprotective effect on C2C12 cells. The myogenin expression level was significantly higher by 1.5 times or more, in the P. ginseng fraction groups than in the other groups, confirming that the P. ginseng fractions promoted cell differentiation. Both fractions of P. ginseng significantly reduced the rate of production of reactive oxygen species when compared with that of the control group. In the mechanism study, P. ginseng fractions tended to decrease muscle RING-finger protein-1 (MuRF-1), AMP-activated protein kinase (AMPK), forkhead box O3α (Foxo3α), and the expression of the BCL2-associated agonist of cell death (BAD). In particular, AMPK was significantly reduced in the P. ginseng water fraction group when compared to that in the butanol fraction and control groups.
Conclusions: The results of this study confirmed that P. ginseng has superior cell differentiation-promoting and protective effects on muscle cells when compared with the effects of Panax quinquefolium and Panax notoginseng.
Methods and Results: In this study, these effects on muscle cells were confirmed using butanol and water fractions of various ginseng species. The fractions of P. ginseng were confirmed to have a cytoprotective effect on C2C12 cells. The myogenin expression level was significantly higher by 1.5 times or more, in the P. ginseng fraction groups than in the other groups, confirming that the P. ginseng fractions promoted cell differentiation. Both fractions of P. ginseng significantly reduced the rate of production of reactive oxygen species when compared with that of the control group. In the mechanism study, P. ginseng fractions tended to decrease muscle RING-finger protein-1 (MuRF-1), AMP-activated protein kinase (AMPK), forkhead box O3α (Foxo3α), and the expression of the BCL2-associated agonist of cell death (BAD). In particular, AMPK was significantly reduced in the P. ginseng water fraction group when compared to that in the butanol fraction and control groups.
Conclusions: The results of this study confirmed that P. ginseng has superior cell differentiation-promoting and protective effects on muscle cells when compared with the effects of Panax quinquefolium and Panax notoginseng.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
REFERENCES
참고문헌 (30)
참고문헌 신청
Chen C / 2020 / Effect of quercetin on dexamethasone-Induced C2C12 skeletal muscle cell injury / Molecules 25:3267
최동준 / 2006 / Clinical Effects of Korean Ginseng, Korean Red Ginseng, Chinese Ginseng, and American Ginseng on Blood Pressure in Mild Hypertensive Subjects / 대한한의학회지 27(4):199~210
최은옥 / 2017 / C2C12 근아세포의 산화적 손상에 대한 고삼, 감초 및 백선피 복합 추출물의 보호효과 / 대한한의학 방제학회지 25(2):179~191
Choi YD / 1998 / Effect of Korean red ginseng on the rabbit corpus cavernosal smooth muscle / International Journal of Impotence Research 10:37~43
최영현 / 2015 / C2C12 근아세포에서 산자나무 유래 Isorhamnetin의 산화적스트레스에 의한 Apoptosis 유발 억제 효과 / 한방비만학회지 15(2):93~103
최동준 / 2006 / Clinical Effects of Korean Ginseng, Korean Red Ginseng, Chinese Ginseng, and American Ginseng on Blood Pressure in Mild Hypertensive Subjects / 대한한의학회지 27(4):199~210
최은옥 / 2017 / C2C12 근아세포의 산화적 손상에 대한 고삼, 감초 및 백선피 복합 추출물의 보호효과 / 대한한의학 방제학회지 25(2):179~191
Choi YD / 1998 / Effect of Korean red ginseng on the rabbit corpus cavernosal smooth muscle / International Journal of Impotence Research 10:37~43
최영현 / 2015 / C2C12 근아세포에서 산자나무 유래 Isorhamnetin의 산화적스트레스에 의한 Apoptosis 유발 억제 효과 / 한방비만학회지 15(2):93~103
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Comparison of Ginsenoside Contents in Different Parts of Korean Ginseng (Panax ginseng C.A. Meyer)
한국식품영양과학회 학술대회발표집
2016 .10
-
Antioxidant activities of flower, berry and leaf of Panax ginseng C. A. Meyer
한국식품과학회지
2020 .08
-
Investigation of Phenolic, Flavonoid, and Vitamin Contents in Different Parts of Korean Ginseng (Panax ginseng C.A. Meyer)
한국식품영양과학회 학술대회발표집
2016 .10
-
The Correlation Analysis between the Soil Bacterial Community and Growth Characterization of 13-years-old Wild-simulated Ginseng (Panax ginseng C.A. Meyer)
한국토양비료학회 학술발표회 초록집
2024 .10
-
An Investigation on the Necessities of Shelf-life and Characteristic Changes in Forest-cultivated Ginseng (Panax ginseng C.A. Meyer) Stored in Different Conditions
한국원예학회 학술발표요지
2018 .10
-
Effects of Gamma-ray Irradiation on One-year-old Ginseng in Panax ginseng C. A. Meyer
한국약용작물학회 학술대회논문집
2018 .10
-
Anti-obesity effects of cultivated ginseng, －wild ginseng and －red ginseng extracts
한국식품영양과학회 학술대회발표집
2019 .10
-
Occurrence and distribution of Watermelon mosaic virus in Ginseng (Panax ginseng) in Korea
한국농약과학회 학술발표대회 논문집
2018 .10
-
Current Review on Korean Red Ginseng Antiviral Activity
한국식품영양과학회 학술대회발표집
2021 .10
-
경기지역에서의 신육성 계통 4년생 인삼의 생육특성
한국약용작물학회 학술대회논문집
2015 .05
-
Study on the appearance characteristics of black ginseng (Panax ginseng C. A. Meyer) by drying methods
한국약용작물학회 학술대회논문집
2021 .05
-
Evaluation of Activity in Muscle Cells using Fractions of Various Ginseng Species
한국약용작물학회 학술대회논문집
2020 .10
-
Comparison of Flavor Attributes and Chemical Composition of Panax ginseng and Panax quinquefolium
한국식품영양과학회 학술대회발표집
2024 .10
-
The Correlation between Soil Properties and Growth Characteristics of Wild-simulated Ginseng (Panax ginseng C. A. Meyer) Seedling in Different Forest Physiognomy
한국토양비료학회 학술발표회 초록집
2020 .10
-
주요 인삼 재배 지역별 3년생 품종의 생육특성
한국약용작물학회 학술대회논문집
2015 .05
-
Comparative Study of Soil Type and Organic Fertilizer Effects on Lipophilic Nutrients in Korean Ginseng (Panax ginseng Meyer)
한국약용작물학회 학술대회논문집
2018 .05
-
원료삼 크기와 형태가 흑삼의 품질에 미치는 영향
한국식품영양학회지
2016 .10
-
Enhancement of Rd Content of White Ginseng (Panax ginseng C.A. Meyer) Extract by Enzyme Treatment
한국약용작물학회 학술대회논문집
2019 .10
-
Water Consumption Patterns and Crop Coefficients by Growth Period of Ginseng (Panax ginseng C.A. Meyer)
한국약용작물학회 학술대회논문집
2022 .10
-
Development of Heat Resistant Lines from Ginseng (Panax ginseng C. A. Meyer) Germplasms
한국약용작물학회 학술대회논문집
2016 .10
이 논문의 저자 정보
이 논문과 함께 이용한 논문
최근 본 자료
댓글(0)
0