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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.5
- 수록면
- 63 - 63 (1page)
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이 논문의 연구 히스토리 (2)
2021
Network Pharmacology of Compounds from Sorghum bicolor with Target Proteins related to Diabetes Mellitus
Ki Kwang Oh
,
Md Adnan
,
Dong Ha Cho
한국약용작물학회 학술대회논문집
2021.05
학술대회자료
Identification of Chemical Compounds and Pharmacological Mechanisms of Phellinus linteus (Grown on Rosa multiflora) for Alleviation of Type 2 Diabetes Mellitus through Network Pharmacology
Ki Kwang Oh
,
Md Adnan
,
Dong Ha Cho
한국약용작물학회 학술대회논문집
2021.05
학술대회자료
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Background : Sorghum bicolor (SB) is rich in protective phytoconstituents with health benefits and regarded as a promising source of natural anti-diabetic substance. However, its comprehensive bioactive compound(s) and mechanism(s) against type-2 diabetes mellitus (T2DM) have not been exposed. Hence, we implemented network pharmacology to identify its key compounds and mechanism(s) against T2DM.
Methods and Results : Compounds in SB were explored through GC-MS and screened by Lipinski’s rule. Genes associated with the selected compounds or T2DM were extracted from public databases, and the overlapping genes between SB-compound related genes and T2DM target genes were identified using Venn diagram. Then, the networking between selected compounds and overlapping genes was constructed, visualized, and analyzed by RStudio. Finally, affinity between compounds and genes was evalu ... 전체 초록 보기
Methods and Results : Compounds in SB were explored through GC-MS and screened by Lipinski’s rule. Genes associated with the selected compounds or T2DM were extracted from public databases, and the overlapping genes between SB-compound related genes and T2DM target genes were identified using Venn diagram. Then, the networking between selected compounds and overlapping genes was constructed, visualized, and analyzed by RStudio. Finally, affinity between compounds and genes was evalu ... 전체 초록 보기
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