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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.5
- 수록면
- 62 - 62 (1page)
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이 논문의 연구 히스토리 (2)
2021
Network Pharmacology of Compounds from Sorghum bicolor with Target Proteins related to Diabetes Mellitus
Ki Kwang Oh
,
Md Adnan
,
Dong Ha Cho
한국약용작물학회 학술대회논문집
2021.05
학술대회자료
Identification of Chemical Compounds and Pharmacological Mechanisms of Phellinus linteus (Grown on Rosa multiflora) for Alleviation of Type 2 Diabetes Mellitus through Network Pharmacology
Ki Kwang Oh
,
Md Adnan
,
Dong Ha Cho
한국약용작물학회 학술대회논문집
2021.05
학술대회자료
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Background : Phellinus linteus (mushroom) grown on Rosa multiflora (PL@RM), exposed beneficial effect and safety on Type 2 diabetes mellitus (T2DM) from Korean folk remedies. However, its active chemical constituents and mechanism(s) against T2DM have not been confirmed. Hence, we deciphered the active compounds and mechanism(s) of PL@RM against T2DM through network pharmacology.
Methods and Results : GC–MS of PL@RM manifested 54 compounds and drugꠓlikeness properties of these compounds were confirmed by Lipinski’s rule. The compound (40) related genes were composed of Similarity Ensemble Approach (SEA) and SwissTargetPrediction (STP). The overlapping genes (61) between the two databases were identified. Besides, the T2DM related genes (4,736) were extracted from DisGeNet and OMIM database. In parallel, a Venn diagram was constructed between the overlapping genes (61) and T2DM related genes (4,736), and finally, 48 genes ... 전체 초록 보기
Methods and Results : GC–MS of PL@RM manifested 54 compounds and drugꠓlikeness properties of these compounds were confirmed by Lipinski’s rule. The compound (40) related genes were composed of Similarity Ensemble Approach (SEA) and SwissTargetPrediction (STP). The overlapping genes (61) between the two databases were identified. Besides, the T2DM related genes (4,736) were extracted from DisGeNet and OMIM database. In parallel, a Venn diagram was constructed between the overlapping genes (61) and T2DM related genes (4,736), and finally, 48 genes ... 전체 초록 보기
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