지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.5
- 수록면
- 64 - 64 (1page)
이용수
초록· 키워드
오류제보하기
Background : Hibiscus cannabinus L. leaves (HCLLs) are considered as a favorable source of natural antiobesity substance. However, its actual bioactive compound(s) and mechanism(s) against obesity have not been confirmed. Hence, network pharmacology was conducted to identify its key compounds and mechanism(s) against obesity.
Methods and Results : Compounds in HCLLs identified through GC-MS analysis and screened by Lipinski's rule. Genes related to the selected compounds and obesity were obtained from public databases, and the overlapping genes between HCLLs compound-related genes and obesity target genes were selected using a Venn diagram. The networking between selected compounds and overlapping genes was then constructed, visualized, and analyzed by RStudio. Finally, the binding affinity between compounds and genes was evaluated via molecular docking (MD). A total of 30 compounds in HCLLs were detected via GC-MS, and Lipinski's rule accepted all compounds. The compounds-related genes (570 genes) and o ... 전체 초록 보기
Methods and Results : Compounds in HCLLs identified through GC-MS analysis and screened by Lipinski's rule. Genes related to the selected compounds and obesity were obtained from public databases, and the overlapping genes between HCLLs compound-related genes and obesity target genes were selected using a Venn diagram. The networking between selected compounds and overlapping genes was then constructed, visualized, and analyzed by RStudio. Finally, the binding affinity between compounds and genes was evaluated via molecular docking (MD). A total of 30 compounds in HCLLs were detected via GC-MS, and Lipinski's rule accepted all compounds. The compounds-related genes (570 genes) and o ... 전체 초록 보기
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Network Pharmacology of Compounds from Sorghum bicolor with Target Proteins related to Diabetes Mellitus
한국약용작물학회 학술대회논문집
2021 .05
-
Marine-derived bioactive compound regulates obesity through leptin signaling pathway
한국수산과학회 양식분과 학술대회
2016 .10
-
Identification of Chemical Compounds and Pharmacological Mechanisms of Phellinus linteus (Grown on Rosa multiflora) for Alleviation of Type 2 Diabetes Mellitus through Network Pharmacology
한국약용작물학회 학술대회논문집
2021 .05
-
Enhancing Plant Defense: The Synergy between Biochar and Ca2+ Signaling
한국토양비료학회 학술발표회 초록집
2024 .10
-
Anti-inflammatory Effect of Compound K in Macrophages by Targeting the AKT1-mediated Signaling Pathway
한국약용작물학회 학술대회논문집
2019 .10
-
Anti-Inflammatory Activity of Phellinus linteus through the Inhibition of Activation for MAPKs and NF-κB Pathway
한국식품영양과학회 학술대회발표집
2018 .10
-
Sex Differences in Diet-induced Obesity: Identification of Hub Genes in association with Phenotypes
한국식품영양과학회 학술대회발표집
2022 .10
-
AKT-1 Signaling Pathway Targeted Apoptotic Activity of Compound K in Human Breast Cancer Cells
한국약용작물학회 학술대회논문집
2019 .10
-
Anti-Inflammatory and Anti-Obesity Properties of Food Bioactive Components : Effects on Adipose Tissue
Preventive Nutrition and Food Science
2017 .12
-
Development of Bioactive Compounds for Anti-Sarcopenic Obesity: Multi-Omics Approach for Autophagy and Nutrient-Sensing Pathway Investigation
한국식품영양과학회 학술대회발표집
2022 .10
-
Ecklonia cava extract SeapolynolTM Improves Obesity and Obesity-induced Insulin resistance
한국식품영양과학회 학술대회발표집
2015 .08
-
Andrographolide Activates Nrf2/ARE/HO-1 Pathway in Hippocampal Neuroblastoma Cells and Suppresses Microglial Activation via Aβ42 through Nrf2-Related NFκB Signaling Pathway
한국식품영양과학회 학술대회발표집
2016 .10
-
Pre-determined cell fate by asymmetric expression of signaling pathway-related genes during intrauterine development in chicken
한국가금학회 정기총회 및 학술발표회
2017 .11
-
Comparative Transcriptome Analysis of RNA-seq Data for Identifying Cold-responsive Genes of Korean Tea Cultivars
한국원예학회 학술발표요지
2021 .10
-
Identification of Anti-Obesity Compounds from Pepper (Capsicum annuum L.) Seeds and Elucidation of Its Anti-Obesity Molecular Mechanisms
한국식품영양과학회 학술대회발표집
2020 .10
-
Exploring the Therapeutic Potentials and Molecular Mechanisms of Coscinium fenestratum Alkaloids in Ulcerative Colitis: An Integrative Network Pharmacology and Molecular Docking Approach
Preventive Nutrition and Food Science
2024 .12
-
Transcriptome profiling of the coffee (C. arabica L.) seedlings under salt stress condition
Journal of Plant Biotechnology
2018 .01
-
Effect of MAP2K6 Gene Overexpression on Obesity in C57BL/6 Mice
한국식품영양과학회 학술대회발표집
2020 .10
-
Analysis of MAPK Signaling Pathway Genes in the Intestinal Mucosal Layer of Necrotic Eenteritis-Afflicted Two Inbred Chicken Lines
한국가금학회지
2017 .09
-
Probiotic Lactobacilli Enhance Metabolic Health in a High-Fat Diet-Induced Obesity in Mice via Regulating the PPARα Signal Pathway
한국식품영양과학회 학술대회발표집
2022 .10
이 논문의 저자 정보
최근 본 자료
댓글(0)
0