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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 397 - 401 (5page)
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초록· 키워드
오류제보하기
Hair graying is an obvious sign of human aging. Although graying has been investigated extensively, the mechanism remains unclear. Here, we reviewed previous studies on the mechanism of graying and seek to offer some new insights. The traditional view is that hair graying is caused by exhaustion of the pigmentary potential of the melanocytes of hair bulbs. Melanocyte dysfunction may be attributable to the effects of toxic reactive oxygen species on melanocyte nuclei and mitochondria. A recent study suggests that bulge melanocyte stem cells (MSCs) are the key cells in play. Graying may be caused by defective MSC self-maintenance, not by any deficiency in bulbar melanocytes. Our previous study suggested that graying may be principally attributable to active hair growth. Active hair growth may produce oxidative or genotoxic stress in hair bulge. These internal stress may cause eventually depletion of MSC in the hair follicles. Taken together, hair graying may be caused by MSC depletion by genotoxic stress in the hair bulge. Hair graying may also be sometimes caused by dysfunction of the melanocytes by oxidative stress in the hair bulb. In addition, hair graying may be attributable to MSC depletion by active hair growth.
목차
등록된 정보가 없습니다.
참고문헌 (48)
참고문헌 신청
Keogh EV / 1965 / Rate of greying of human hair / Nature 207:877~878
Panhard S / 2012 / Greying of the human hair: a worldwide survey, revisiting the '50' rule of thumb / Br J Dermatol 167:865~873
Lison M / 1981 / Progressive spastic paraparesis, vitiligo, premature graying, and distinct facial appearance: a new genetic syndrome in 3 sibs / Am J Med Genet 9:351~357
Shin H / 2015 / Association of premature hair graying with family history, smoking, and obesity: a cross-sectional study / J Am Acad Dermatol 72:321~327
Tobin DJ / 2001 / Graying: gerontobiology of the hair follicle pigmentary unit / Exp Gerontol 36:29~54
Panhard S / 2012 / Greying of the human hair: a worldwide survey, revisiting the '50' rule of thumb / Br J Dermatol 167:865~873
Lison M / 1981 / Progressive spastic paraparesis, vitiligo, premature graying, and distinct facial appearance: a new genetic syndrome in 3 sibs / Am J Med Genet 9:351~357
Shin H / 2015 / Association of premature hair graying with family history, smoking, and obesity: a cross-sectional study / J Am Acad Dermatol 72:321~327
Tobin DJ / 2001 / Graying: gerontobiology of the hair follicle pigmentary unit / Exp Gerontol 36:29~54
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