지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.9
- 수록면
- 187 - 194 (8page)
이용수
초록· 키워드
오류제보하기
Human immunodeficiency virus-1 (HIV-1) encodes an accessory protein Nef. Initially, Nef had been known as a viral negative factor due to its no-effect on viral replication in the cancerous cell line system, however the pivotal role of Nef in disease progression has been discovered in primary culture and in vivo studies. The Nef protein is 27-35kDa, which is N-myristolated to attach on the intracellular membrane. Since it is already known that the nef-deleted virus is associated with long-term non-progression (LTNP), the roles of Nef linked to viral virulence were emphasized to develop an agent capable of inhibiting the progression of acquired immunodeficiency syndrome (AIDS). Nef plays multifaceted roles in host cell activities, which are recognized as the key functions of Nef-induced AIDS progression. Nef down-regulates the surface expression of several immune proteins including CD4, major histocompatibility complex class I (MHC-I/II), CD3. CD62L CXCR4, etc. Also, Nef disturbs the actin dynamics linked to vesicle trafficking and cell movement, and modulates the T-cell activation signaling associated with viral transcription. Here, we overview the molecular mechanisms of Nef with regard to AIDS pathogenesis and discuss various therapeutic approaches targeting Nef with a view to developing a new class of anti-AIDS agent capable of preventing the disease progression linked to Nef-induced CD4 down-regulation and HIV-1 replication.
목차
INTRODUCTION
CLOSING REMARKS
REFERENCES
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Malignancy risk of thyroid nodules with nonshadowing echogenic foci
ULTRASONOGRAPHY
2021 .01
-
Genetic defects in the nef gene are associated with Korean Red Ginseng intake : monitoring of nef sequence polymorphisms over 20 years
Journal of Ginseng Research
2017 .04
-
Impact of HIV-1 subtypes on gross deletion in the nef gene after Korean Red Ginseng treatment
Journal of Ginseng Research
2022 .11
-
Recent update in HIV vaccine development
Clinical and Experimental Vaccine Research
2016 .01
-
Effect of Korean Red Ginseng intake on the survival duration of human immunodeficiency virus type 1 patients
Journal of Ginseng Research
2017 .04
-
Outbreaks and patterns of HIV/AIDS in advanced Asian countries
대한보건연구
2020 .01
-
Biomarkers for Targeting the HIV-1 Reservoirs
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2021 .03
-
Importance of various oral manifestations regardless of CD4 cell count in HIV/AIDS patients
대한구강악안면외과학회지
2018 .01
-
사람면역결핍바이러스 감염 및 후천면역결핍증후군의 역학
대한의사협회지
2024 .03
-
The 2018 Clinical Guidelines for the Diagnosis and Treatment of HIV/AIDS in HIV-Infected Koreans
Infection and Chemotherapy
2019 .01
-
Oral Manifestations of Human Immunodeficiency Virus Infection: Early Diagnostic Indicators
Journal of Oral Medicine and Pain
2024 .09
-
Summary of 2021 Clinical Guidelines for the Diagnosis and Treatment of HIV/AIDS in HIV-infected Koreans
Infection and Chemotherapy
2021 .09
-
Transcriptome Analysis Identifies Altered Biological Processes and Novel Markers in Human Immunodeficiency Virus-1 Long-Term Non-Progressors
Infection and Chemotherapy
2021 .09
-
Molecular Epidemiology of Human Immunodeficiency Virus
Infection and Chemotherapy
2017 .01
-
Current Status of the Estimation on the Number of People Who Living with HIV and the Rate of Undiagnosed Cases
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2020 .09
-
Successive Term Delivery in Women with Stable Human Immunodeficiency Virus Infection: A Case Report
Perinatology
2024 .09
-
The HIV Care Cascade in Korea: Status of UNAIDS 90-90-90 Targets
Journal of Korean Medical Science
2020 .01
-
사람면역결핍바이러스 감염인 및 후천면역결핍증후군 환자에 대한 사회적 낙인과 차별
대한의사협회지
2024 .03
-
남성동성애의 차별금지에 대한 HIV/AIDS 감염예방 측면에서의 공중보건학적 해석
대한보건연구
2016 .01
-
The Effects of Socio-demographic Characteristics on Indonesian Women’s Knowledge of HIV/AIDS: A Cross-sectional Study
예방의학회지
2019 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2020-475-001284876