지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.4
- 수록면
- 222 - 226 (5page)
이용수
초록· 키워드
오류제보하기
Background: Long-term ginseng intake can increase longevity in healthy individuals. Here, we examined if long-term treatment with Panax ginseng Meyer (Korean Red Ginseng, KRG) can also enhance survival duration (SD) in patients with human immunodeficiency virus type 1 (HIV-1) infection.
Methods: We retrospectively analyzed 252 HIV-1 patients diagnosed from 1986 to 2013 prior to the initiation of antiretroviral therapy. Overall, 162 patients were treated with KRG (3,947 ± 4,943 g) for 86 ± 63 mo. The effects of KRG on SD were analyzed according to the KRG intake level and the length of the follow-up period.
Results: There were significant correlations between the total amount of KRG and SD in the KRG intake group (r = 0.64, p < 0.0001) as well as between total amount of KRG and mean annual decrease in CD4<SUP>+</SUP> T-cell count in all 252 patients (r = - 0.17, p < 0.01). The annual decrease in CD4<SUP>+</SUP> T-cell count (change in cells/mL) was significantly slower in KRG-treated patients than in patients receiving no KRG (48 ± 40 vs. 106 ± 162; p < 0.001). The SD (in months) was also significantly longer in the KRG group than in the no-KRG group (101 ± 64 vs. 59 ± 40, p < 0.01).
Conclusion: KRG prolongs survival in HIV-1 patients, possibly by slowing the decrease in CD4<SUP>+</SUP> T-cell count.
Methods: We retrospectively analyzed 252 HIV-1 patients diagnosed from 1986 to 2013 prior to the initiation of antiretroviral therapy. Overall, 162 patients were treated with KRG (3,947 ± 4,943 g) for 86 ± 63 mo. The effects of KRG on SD were analyzed according to the KRG intake level and the length of the follow-up period.
Results: There were significant correlations between the total amount of KRG and SD in the KRG intake group (r = 0.64, p < 0.0001) as well as between total amount of KRG and mean annual decrease in CD4<SUP>+</SUP> T-cell count in all 252 patients (r = - 0.17, p < 0.01). The annual decrease in CD4<SUP>+</SUP> T-cell count (change in cells/mL) was significantly slower in KRG-treated patients than in patients receiving no KRG (48 ± 40 vs. 106 ± 162; p < 0.001). The SD (in months) was also significantly longer in the KRG group than in the no-KRG group (101 ± 64 vs. 59 ± 40, p < 0.01).
Conclusion: KRG prolongs survival in HIV-1 patients, possibly by slowing the decrease in CD4<SUP>+</SUP> T-cell count.
목차
ABSTRACT
1. Introduction
2. Materials and methods
3. Results
4. Discussion
References
참고문헌 (33)
참고문헌 신청
[학술지(정기간행물)] - Perelson AS / 1996 / HIV-1 dynamics in vivo:virion clearance rate, infected cell life-span, and viral generation time / Science 271 : 1582 ~ 1586
[학술지(정기간행물)] - Pantaleo G / 1993 / New concepts in the immunopathogenesis of human immunodeficiency virus infection / N Engl J Med 328 : 327 ~ 335
[학술지(정기간행물)] - Palella Jr FJ / 1998 / Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV outpatient study investigators / N Engl J Med 338 : 853 ~ 860
[학술지(정기간행물)] - INSIGHT START Study Group / 2015 / Initiation of antiretroviral therapy in early asymptomatic HIV infection / N Engl J Med 373 : 795 ~ 807
[학술지(정기간행물)] - Lorenzo-Redondo R / 2016 / Persistent HIV-1 replication maintains the tissue reservoir during therapy / Nature 530 : 51 ~ 56
[학술지(정기간행물)] - Pantaleo G / 1993 / New concepts in the immunopathogenesis of human immunodeficiency virus infection / N Engl J Med 328 : 327 ~ 335
[학술지(정기간행물)] - Palella Jr FJ / 1998 / Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV outpatient study investigators / N Engl J Med 338 : 853 ~ 860
[학술지(정기간행물)] - INSIGHT START Study Group / 2015 / Initiation of antiretroviral therapy in early asymptomatic HIV infection / N Engl J Med 373 : 795 ~ 807
[학술지(정기간행물)] - Lorenzo-Redondo R / 2016 / Persistent HIV-1 replication maintains the tissue reservoir during therapy / Nature 530 : 51 ~ 56
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UCI(KEPA) : I410-ECN-0101-2018-524-001598890