지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 11 - 20 (10page)
이용수
초록· 키워드
오류제보하기
Objectives : Ongyeong-tang (OGT) is a traditional herbal formula used to cure gynaecological disorders. OGT consists of 12 herbal medicines containing various bioactive components. Therefore, the development of suitable analytical method for the marker compounds is necessary for the quality control of OGT. Methods : Determination of the 18 marker compounds in OGT preparations was quantitatively performed by high-performance liquid chromatography-photodiode array detection analysis. The marker compounds were separated on a reversed-phase C <sub>18</sub> column and the analytical method was successfully validated, which was applied to compare OGT extracts from laboratory preparation and commercial OGT granules. Results : Limit of detection and limit of quantification values were in the ranges of $0.001-0.016{\mu}g/mL$ and $0.003-0.047{\mu}g/mL$, respectively. Precision was 0.03-3.71 % within a day and 0.03-3.81 % over four consecutive days. Recovery of marker compounds ranged from 90.63-108.26 %, with relative standard deviation (RSD) values < 4.0 %. Reproducibility was < 2.5 % of the RSD value. The 18 marker compounds were stable within 16 h at $10^{\circ}C$, with the RSD value < 3.5 %. Quantitative analysis results showed that the quantities of the 18 marker compounds varied among OGT samples. Pearson coefficient evaluation and principal component analysis demonstrated that an OGT water extract produced by a laboratory method clearly differed from commercial OGT granules. Conclusions : The developed analytical method was simple, precise, and reliable. Therefore, it can be used for the quality assessment of OGT preparations.
목차
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참고문헌 (34)
참고문헌 신청
The Korean Medicine Society for the Herbal Formula Study / 2003 / Herbal formula / Younglimsa :420
Ushiroyama T / 1995 / The Effect of Unkei-to on pituitary gonadotropin secretion and ovulation in anovulatory cycles of young women / Am J Chin Med 23:223~230
Ushiroyama T / 2001 / Effects of unkei-to, an herbal medicine, on endocrine function and ovulation in women with high basal levels of luteinizing hormone secretion / J Reprod Med 46:451~456
Ushiroyama T / 2003 / Effects of Unkei-to on FSH, LH and estradiol in anovulatory young women with hyperor hypo-functioning conditions / Am J Chin Med 31:763~771
Koike K / 2004 / Efficacy of the herbal medicine Unkei-to as an adjunctive treatment to hormone replacement therapy for postmenopausal women with depressive symptoms / Clin Neuropharmacol 27:157~162
Ushiroyama T / 1995 / The Effect of Unkei-to on pituitary gonadotropin secretion and ovulation in anovulatory cycles of young women / Am J Chin Med 23:223~230
Ushiroyama T / 2001 / Effects of unkei-to, an herbal medicine, on endocrine function and ovulation in women with high basal levels of luteinizing hormone secretion / J Reprod Med 46:451~456
Ushiroyama T / 2003 / Effects of Unkei-to on FSH, LH and estradiol in anovulatory young women with hyperor hypo-functioning conditions / Am J Chin Med 31:763~771
Koike K / 2004 / Efficacy of the herbal medicine Unkei-to as an adjunctive treatment to hormone replacement therapy for postmenopausal women with depressive symptoms / Clin Neuropharmacol 27:157~162
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