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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 137 - 145 (9page)
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초록· 키워드
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Saengmaek-san (SMS) comprises three herbal medicines Liriopis seu Ophiopogonis Tuber, Ginseng Radix, and Schisandrae Fructus. SMS has been traditionally used for the treatment of ischemic disease in Asia. In this study, an analytical method using high-performance liquid chromatography (HPLC) and a photodiode array detector (PDA) (HPLC–PDA) was used for the quantitative analysis of schizandrin and gomisin A in SMS, a traditional herbal formula. Chromatographic separation of the two compounds was carried out using a Gemini C18 column and two mobile phases, distilled water and acetonitrile, with gradient elution. The coefficient of determination of the calibration curve for the quantitative analysis of the marker components of Schisandrae Fructus in an SMS sample, schizandrin and gomisin A, was 1.0000. The limit of detection of the marker components was 3.28 mg/mL and 3.19 mg/mL, and the limit of quantification was 9.93 mg/mL and 9.67 mg/mL. Recovery and intra- and interday precisions were 95.44-103.58% and < 1.5%, respectively. The quantities of schizandrin and gomisin A were 0.244 and 0.028 mg/freeze-dried g, respectively. The optimized HPLC–PDA method could be expected to provide basic data for the quality control of SMS and other related herbal formulas.
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참고문헌 (14)
참고문헌 신청
Heo, J. / 2007 / Donguibogam / Namsandang :410
문효 / 2012 / 生脈散과 生脈散加味方이 NC/Nga 마우스의 아토피 피부염에 미치는 영향에 대한 비교 연구 / 한방안이비인후피부과학회지 25(1):33~54
Jeong MY / 2013 / Saengmaeksan inhibits inflammatory mediators by suppressing RIP-2/caspase-1 activation / Immunopharmacology and Immunotoxicology 35:241~250
Wang NL / 2005 / Shengmai san, a Chinese herbal medicine protects against rat heat stroke by reducing inflammatory cytokines and nitric oxide formation / Journal of Pharmacolical Sciences 98:1~7
Wang L / 2003 / Prevention of oxidative injury in PC12 cells by a traditional Chinese medicine, Shengmai san, as a model of an antioxidant-based composite formula / Biological & Pharmaceutical Bulletin 26:1000~1004
문효 / 2012 / 生脈散과 生脈散加味方이 NC/Nga 마우스의 아토피 피부염에 미치는 영향에 대한 비교 연구 / 한방안이비인후피부과학회지 25(1):33~54
Jeong MY / 2013 / Saengmaeksan inhibits inflammatory mediators by suppressing RIP-2/caspase-1 activation / Immunopharmacology and Immunotoxicology 35:241~250
Wang NL / 2005 / Shengmai san, a Chinese herbal medicine protects against rat heat stroke by reducing inflammatory cytokines and nitric oxide formation / Journal of Pharmacolical Sciences 98:1~7
Wang L / 2003 / Prevention of oxidative injury in PC12 cells by a traditional Chinese medicine, Shengmai san, as a model of an antioxidant-based composite formula / Biological & Pharmaceutical Bulletin 26:1000~1004
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