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Trends in System-level Research on Quality Control of Complex Herbal Formulation
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복합 처방 품질 관리를 위한 시스템 차원의 연구 동향

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Type
Academic journal
Author
Doo Suk Lee (바이로메드) Young Woo Kim (대구한의대학교)
Journal
The Society of Pathology in Korean Medicine Journal of Physiology & Pathology in Korean Medicine Vol.30 No.6 KCI Accredited Journals
Published
2016.12
Pages
397 - 401 (5page)
DOI
10.15188/kjopp.2016.12.30.6.397

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Trends in System-level Research on Quality Control of Complex Herbal Formulation
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The quality control is a fundamental procedure for the standardization of herbal medicine to guarantee the consistency of efficacy and safety. For a long time, the quality analysis of herbal medicine has been largely dependent on the routine sensory evaluation, such as taste, smell, color, and shape. However, with the recent development of analytical instruments, various scientific approaches have been introduced in this field. On the basis of the theory that the biological activities of herbal medicine are mainly contributed by its chemical compositions, several types of chemical markers have been suggested for the quality evaluation. In addition to the analytical methods for the specific marker compound(s), including analytical marker and active marker, recently, chemical fingerprinting, a method comparing the chromatographic pattern of the whole chemical components, has been developed and widely accepted as a reliable approach for the quality control of herbal medicine. Moreover, in order to exactly understand the relationship between complex compounds and their holistic biological activities in herbal medicine, unique strategies, such as “BECCs (bioactive equivalent combinatorial components)” and “PhytomicsQC” have been established. In this article, we give an overview of the several categories of chemical markers and the recent research trends for the quality evaluation of herbal medicine.
#Quality control #Herbal medicine #Chemical markers #Biological activities

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[학술지(정기간행물)] - Morrow, J. K. / 2010 / Molecular networks in drug discovery / Crit Rev Biomed Eng 38 (2) : 143 ~ 156 google schola [학술지(정기간행물)] - Li, S. / 2014 / Network pharmacology in traditional chinese medicine / Evid Based Complement Alternat Med 2014 : 138460 ~ google schola [학술지(정기간행물)] - Science AAftAo / 2015 / The Art and Science of Traditional Medicine Part 2: Multidisciplinary Approaches for Studying Traditional Medicine / Science 347 (6219) : 337 ~ google schola [보고서] - Shon, Y. / 2015 / Guideline for quality control of herbal extract google schola [학술지(정기간행물)] - Chan, S. K. / 2007 / Pitfalls of the selection of chemical markers for the quality control of medicinal herbs / Journal of Food and Drug Analysis 15 (4) google schola

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UCI(KEPA) : I410-ECN-0101-2017-519-001974775