Relations of Serum Visfatin and Resistin Levels with Endometrial Cancer and Factors Associated with its Prognosis

Ilhan, Tolgay Tuyan; Kebapcilar, Aysegul; Yilmaz, Setenay Arzu; Ilhan, Turkan; Kerimoglu, Ozlem Secilmis; Pekin, Aybuke Tazegul; Akyurek, Fikret; Unlu, Ali; Celik, Cetin

추천

검색

자료유형: 학술저널

저자정보: Ilhan, Tolgay Tuyan (Gynecologic Oncology, Medical Faculty, University of Selcuk) Kebapcilar, Aysegul (Gynecology, Medical Faculty, University of Selcuk) Yilmaz, Setenay Arzu (Gynecology, Medical Faculty, University of Selcuk) Ilhan, Turkan (Beyhekim State Hospital) Kerimoglu, Ozlem Secilmis (Gynecology, Medical Faculty, University of Selcuk) Pekin, Aybuke Tazegul (Gynecology, Medical Faculty, University of Selcuk) Akyurek, Fikret (Biochemistry, Medical Faculty, University of Selcuk) Unlu, Ali (Biochemistry, Medical Faculty, University of Selcuk) Celik, Cetin (Gynecologic Oncology, Medical Faculty, University of Selcuk)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제16권 제11호

발행연도: 2015.1

수록면: 4,503 - 4,508 (6page)

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

Background: The aims of this study were compare the serum visfatin and resistin levels between endometrial cancer (EC) patients and controls and evaluate their power to predict prognosis. Materials and Methods: This prospective study was conducted between March 2013 to June 2014 on the Gynecologic Oncology Department of the University of Selcuk, Konya, Turkey. A total of 42 EC patients and 42 controls were included and assessed for differences in serum visfatin and resistin levels, along with prognostic factors. Results: Endometrial cancer patients had significantly higher visfatin levels than control s (p: 0.011), associated with deep myometrial invasion (p: 0.019). In contrast the serum level of resistin did not significantly differ between EC patients and controls (p: 0.362). However, high resistin level in EC patients was associated with increase lymph node metastasis (p: 0.009). On logistic regression analysis, we found that serum visfatin elevation was associated with risk of myometrial invasion (OR: 1,091; 95%CI: 1.021-1.166; p: 0.010) and serum resistin with risk of lymph node metastasis (OR: 1.018; 95%CI: 1.000-1.035; p: 0.046). For myometrial invasion prediction, a serum visfatin level greater than 26.8 ng/mL demonstrated a sensitivity and specificity of 66.6 % and 96.4%, respectively. For lymph node metastasis prediction, the best cut-off for serum resistin level was 599ng/mL. A serum resistin level greater than this demonstrated a sensitivity and specificity of 87.5% and 77.1%, respectively. Conclusions: Our data suggest that serum visfatin is elevated in patients with EC and serum visfatin and resistin levels could be used to predict the risk of advance stage lesions.

#Visfatin #resistin #endometrial cancer #adipocytokine

참고문헌 (0)

참고문헌 신청

참고문헌이 DBpia에서 서비스 중이라면, [참고문헌 신청]을 통해 등록해보세요

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!