The Value of Preoperative CA 125 Levels in Prediction of Myometrial Invasion in Patients with Early-stage Endometrioid-type Endometrial Cancer

Atguden, Zeynep; Yildiz, Askin; Aksut, Hayri; Yalcin, Serenat Eris; Yalcin, Yakup; Uysal, Dilek; Yetimalar, Hakan

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저자정보: Atguden, Zeynep (Gynecology and Obstetrics Department, Akropol Medical Hospital) Yildiz, Askin (Gynecology and Obstetrics Department, Ataturk Training and Research Hospital) Aksut, Hayri (Gynecology and Obstetrics Department, Soma State Hospital) Yalcin, Serenat Eris (Perinatology Department, Suleyman Demirel University) Yalcin, Yakup (Gynecologic Oncology Department of Suleyman Demirel University) Uysal, Dilek (Gynecology and Obstetrics Department, Ataturk Training and Research Hospital) Yetimalar, Hakan (Oncology Department, Ataturk Training and Research Hospital)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제17권 제2호

발행연도: 2016.1

수록면: 497 - 501 (5page)

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Aim: To evaluate the relationship between pre-operative CA-125 levels and myometrial invasion in patients with early-stage endometrioid-type endometrial cancer. Materials and Methods: Two-hundred and sixty patients were diagnosed with endometrial cancer between January 2007 and December 2012. Of these, 136 patients with stage 1 endometrioid histologic-type and documented pre-operative serum CA-125 levels were included in the study. Age, preoperative CA-125 level, histologic grade, surgical grade, and presence of deep myometrial invasion were recorded. Additionally, 16, 20, and 35 IU/ml cutoff values were used and compared to evaluate the relationship between pre-operative CA-125 levels and myometrial invasion. Results: The average serum CA-125 level was $35.4{\pm}36.7$ in patients with deep myometrial invasion, and $21.5{\pm}35.8$ in cases without deep myometrial invasion. The relationship between the presence of deep myometrial invasion and CA-125 cut-off values (16, 20, 35 IU/ml) was statistically significant, although the correlation was weak (p<0.05). When the relationship between 16, 20 and 35 IU/ml CA-125 cut-off values and the presence of deep myometrial invasion was studied, specifity and sensitivity values were identified as: 0.60-0.68 for 16 IU/ml; 0.73-0.48 for 20 IU/ml; and 0.89-0.33 for 35 IU/ml. The sensitivity of 16 IU/ml cut-off value was higher when compared to other values. Conclusions: This study demonstrates that preoperative serum CA-125 values maybe used as a predictive test in patients with early stage endometrioid-type endometrium cancer, and as a prognostic factor alone. Further studies should be conducted to identify different CA-125 cut-off values in patients with low risk endometrial cancer.

#Endometrial cancer #deep myometrial invasion #CA-125 #cut-off value

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