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논문 기본 정보

자료유형
학술저널
저자정보
Bawah Ahmed Tijani (University of Health and Allied Sciences) Yeboah Francis Agyemang (Kwame Nkrumah University Science and Technology) Nanga Salifu (University of Health and Allied Science) Alidu Huseini (University of Health and Allied Science) Ngala Robert A. (Kwame Nkrumah University Science and Technology)
저널정보
대한고혈압학회 Clinical Hypertension Clinical Hypertension 제27권 제1호
발행연도
2021.1
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8 - 18 (11page)

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Abstract Background: This study was aimed at determining the levels of serum adiponectin, leptin, resistin, visfatin and lipids during the first trimester in pregnant women and to evaluate the relationship between these biochemical markers and preeclampsia (PE). Available evidence point to changes in the levels of these adipokines in PE hence this study examined the potential of using these biomarkers in the prediction of the disease. Methods: This was a case-control study which compared first trimester serum biochemical and anthropometric parameters in pregnant women who subsequently developed PE and those who did not. Blood pressure and urine protein were determined after 20 weeks of gestation and diagnosis of PE performed according to the guidelines of the American Heart Association. Results: There was no significant difference (p > 0.05) in the lipid profile with the exception of HDL cholesterol which was significantly lower (p = 0.043) in the PE group compared to the normotensive group. There were, however, significant differences (p < 0.05) in the adipokines between the PE group and those without PE. Analyses of area under the receiver operating characteristic curves (AUCs) for the adipokines, showed their ability to correctly predict PE even after controlling for body mass index (BMI) and family history of hypertension. Conclusion: Adiponectin, leptin, resistin and visfatin were found to be significant predictors of PE, with resistin being the best predictor after controlling for BMI. However, adiponectin was the best predictor after controlling for BMI, age, parity and family history of diabetes and preeclmapsia.

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