Frequency of FLT3 (ITD, D835) Gene Mutations in Acute Myelogenous Leukemia: a Report from Northeastern Iran

Allahyari, Abolghasem; Sadeghi, Masoud; Ayatollahi, Hossein; Yazdi, Hamed Najjaran; Tavakol, Mohammad

추천

검색

자료유형: 학술저널

저자정보: Allahyari, Abolghasem (Department of Hematology-Oncology, Emam Reza Hospital, School of Medicine, Mashhad University of Medical Sciences) Sadeghi, Masoud (Medical Biology Research Center, Kermanshah University of Medical Sciences) Ayatollahi, Hossein (Department of Hematology and Blood Banking, Cancer Molecular Pathology Research Center, Ghaem Hospital, Mashhad University of Medical Sciences) Yazdi, Hamed Najjaran (Department of Internal Medicine, Imam Reza Hospital, Mashhad University of Medical Sciences) Tavakol, Mohammad (Department of Internal Medicine, Imam Reza Hospital, Mashhad University of Medical Sciences)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제17권 제9호

발행연도: 2016.1

수록면: 4,319 - 4,322 (4page)

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

Background: FLT3 is mutated in about 1/3 of acute myelogenous leukemia (AML) patients. The aim of the present study was to report the prevalence of FLT3 mutations and comparison with prognostic factors in AML patients in the Northeastern of Iran. Materials and Methods: This cross-sectional study concerned 100 AML cases diagnosed based on bone marrow aspiration and peripheral blood. DNA for every AML patient was extracted and underwent PCR with FLT3-ITD primers. Results: The mean age at diagnosis was 28.5 years (range, 1-66 years), 52 patients (52%) being male. Out of 100 AML patients, 21 (21%) had FLT3 mutation, (17 with FLT3-ITD, 81%, and 4 with FLT3-D825, 19%). Of the 21, 14 (66.7%) had heterozygous mutation. There was no significant difference between age, sex and organomegaly between patients with FLT3 mutation versus FLT3 wild-type. Conclusions: Our frequency of FLT3 is in line with earlier fidnings of approximately 20 to 30% and also the prevalence of FLT3-ITD is more than FLT3-D35 mutation. There was no significant difference between prognostic factors (age and sex) in the patients with FLT3 mutation versus FLT3 wild-type. The prevalence of FLT3 heterozygous mutations is more that homozygous mutations in AML patients.

#Acute myelogenous leukemia #FLT3 mutation #heterozygous mutation #Northeastern Iran

참고문헌 (0)

참고문헌 신청

참고문헌이 DBpia에서 서비스 중이라면, [참고문헌 신청]을 통해 등록해보세요

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!