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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 327 - 329 (3page)
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Dear Editor, Next-generation sequencing (NGS) is rapidly being adapted in clinical practice, and numerous clinical laboratories are using this technology to assess patients with acute myeloid leukemia (AML). Among recurrent somatic mutations in AML, the FLT3 internal tandem duplication (ITD) has major clinical implications and is associated with adverse outcomes [1-3]. Identification of the mutation is critical for risk stratification and the decision of early hematopoietic stem cell transplantation [2, 3]. Furthermore, as activated kinase targets such as FLT3 and JAK are under active clinical investigation [4, 5], it has become increasingly important to identify activating FLT3 mutations. During NGS, however, accurate mapping and consequent variant calling is not always possible because the duplication size could be small or large, and the inserted segment is essentially, but not necessarily, a part of the normal reference sequence.
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참고문헌 (10)
참고문헌 신청
National Comprehensive Cancer Network / Acute Myeloid Leukemia (Version 2.2018)
Chevallier P / 2011 / A new Leukemia Prognostic Scoring System for refractory/relapsed adult acute myelogeneous leukaemia patients : a GOELAMS study / Leukemia 25:939~944
Döhner H / 2017 / Diagnosis and management of AML in adults : 2017 ELN recommendations from an international expert panel / Blood 129:424~447
Degryse S / 2015 / JAK kinase inhibitors for the treatment of acute lymphoblastic leukemia / J Hematol Oncol 8:91
Wander SA / 2014 / The evolving role of FLT3 inhibitors in acute myeloid leukemia : quizartinib and beyond / Ther Adv Hematol 5:65~77
Chevallier P / 2011 / A new Leukemia Prognostic Scoring System for refractory/relapsed adult acute myelogeneous leukaemia patients : a GOELAMS study / Leukemia 25:939~944
Döhner H / 2017 / Diagnosis and management of AML in adults : 2017 ELN recommendations from an international expert panel / Blood 129:424~447
Degryse S / 2015 / JAK kinase inhibitors for the treatment of acute lymphoblastic leukemia / J Hematol Oncol 8:91
Wander SA / 2014 / The evolving role of FLT3 inhibitors in acute myeloid leukemia : quizartinib and beyond / Ther Adv Hematol 5:65~77
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