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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 269 - 276 (8page)
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Differentiation of neuronal cells has been shown to accelerate stress-induced cell death, but the underlying mechanisms are not completely understood. Here, we find that early and sustained increase in cytosolic ([Ca2+]c) and mitochondrial Ca2+ levels ([Ca2+]m) is essential for the increased sensitivity to staurosporineinduced cell death following neuronal differentiation in PC12 cells. Consistently, pretreatment of differentiated PC12 cells with the intracellular Ca2+-chelator EGTA-AM diminished staurosporine-induced PARP cleavage and cell death. Furthermore, Ca2+ overload and enhanced vulnerability to staurosporine in differentiated cells were prevented by Bcl-XL overexpression.
Our data reveal a new regulatory role for differentiation- dependent alteration of Ca2+ signaling in cell death in response to staurosporine.
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참고문헌 (24)
참고문헌 신청
Beal MF / 1998 / Mitochondrial dysfunction in neurodegenerative diseases / Biochim Biophys Acta 1366 : 211 ~ 223
Boise LH / 1993 / bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death / Cell 74 : 597 ~ 608
Demaurex N / 2003 / Cell biology. Apoptosis--the calcium connection / Science 300 : 65 ~ 67
Desagher S / 2000 / Mitochondria as the central control point of apoptosis / Trends Cell Biol 10 : 369 ~ 377
Dong Z / 2006 / Calcium in cell injury and death / Annu Rev Pathol 1 : 405 ~ 434
Boise LH / 1993 / bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death / Cell 74 : 597 ~ 608
Demaurex N / 2003 / Cell biology. Apoptosis--the calcium connection / Science 300 : 65 ~ 67
Desagher S / 2000 / Mitochondria as the central control point of apoptosis / Trends Cell Biol 10 : 369 ~ 377
Dong Z / 2006 / Calcium in cell injury and death / Annu Rev Pathol 1 : 405 ~ 434
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