Chemical constituents of Dicentra spectabilis and their anti-inflammation effect

Kim, A Hyeon; Jang, Ji Hun; Woo, Kyeong Wan; Park, Jong Eel; Lee, Ki Ho; Jung, Ho Kyung; An, Byeongkwan; Jung, Won Seok; Ham, Seong Ho; Cho, Hyun Woo

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자료유형: 학술저널

저자정보: Kim, A Hyeon (Division of Traditional Korean Medicine Resource, National Development Institute of Korea Medicine) Jang, Ji Hun (Division of Traditional Korean Medicine Resource, National Development Institute of Korea Medicine) Woo, Kyeong Wan (Division of Traditional Korean Medicine Resource, National Development Institute of Korea Medicine) Park, Jong Eel (Division of Traditional Korean Medicine Resource, National Development Institute of Korea Medicine) Lee, Ki Ho (Division of Traditional Korean Medicine Resource, National Development Institute of Korea Medicine) Jung, Ho Kyung (Division of Traditional Korean Medicine Resource, National Development Institute of Korea Medicine) An, Byeongkwan (Division of Traditional Korean Medicine Resource, National Development Institute of Korea Medicine) Jung, Won Seok (Division of Traditional Korean Medicine Resource, National Development Institute of Korea Medicine) Ham, Seong Ho (Division of Traditional Korean Medicine Resource, National Development Institute of Korea Medicine) Cho, Hyun Woo (Division of Traditional Korean Medicine Resource, National Development Institute of Korea M)

저널정보: 한국응용생명화학회 Journal of applied biological chemistry Journal of applied biological chemistry 제61권 제1호

발행연도: 2018.1

수록면: 39 - 46 (8page)

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

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Column chromatographic separation of the MeOH extract from the roots of Dicentra spectabilis yielded fourteen compounds, menisdaurin (1), menisdaurilide (2), trans-N-p-coumaroyltyramine (3), trans-N-p-feruloyltyramine (4), 4-O-feruloylquinicacid (5), chlorogenic acid (6), 3-O-feruloylquinicacid (7), ferulic acid (8), protopine (9), Kaempferol 3,7-di-O-${\beta}-{\text\tiny{D}}$-glucopyranoside (10), kaempferol 3-O-${\beta}-{\text\tiny{D}}$-glucopyranosyl-7-O-${\alpha}-{\text\tiny{L}}$-rhamnopyranoside (11), ${\alpha}-rhamnoisorobin$ (12), astragalin (13), and nicotiflorin (14). Their structures were determined on the basis of NMR spectroscopic data. Among them, compound 1, 3-8, and 10-14 isolated from this plant were reported for the first time. The isolated compounds (1-14) were tested for nitric oxide (NO) inhibitory activity on lipopolysaccharide-stimulated RAW 264.7 cells. Compound 3, 4 and 12 significantly inhibited NO production. Moreover, Compound 3 suppressed pro-inflammatory cytokines ($TNF-{\alpha}$, $IL-1{\beta}$ and IL-6) in a dose- dependent manner. These data suggest that compound 3 possess anti-inflammatory activity and might be useful natural materials for development of anti-inflammatory agent.

#Anti-inflammation effect #Dicentra spectabilis #Fumariaceae #Isolation #Structure elucidation

참고문헌 (29)

참고문헌 신청

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