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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 109 - 123 (15page)
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Purpose : In this study, we intended to observe the anti-wrinkle and moisturizing effects of dried pomegranate juice concentration powder (PCP) using in vitro test. Materials and methods : Antioxidant effects of PCP were determined by free radical scavenging capacity (DPPH assay) and the cytotoxicity of PCP was examined in human keratinocyte (HaCaT) and human primary dermal fibroblast-neonatal (HDF) cells. To investigate the moisturizing effect of PCP, hyaluronan synthesis was examined in HaCaT cells. Activity of procollagen production were assessed in HDF cells and elastase inhibition properties of PCP were evaluated in cell free condition, to determine their anti-wrinkle effects. Metalloproteinase 1 (MMP-1) activity was also assessed following UVB irradiation, in the current in vitro experiment. Results : No PCP treatment related significant cytotoxic effects were demonstrated against to the both HDF and HaCaT cells. PCP showed favorable free radical scavenging activities in dose-dependent manner. In PCP-treated HaCaT cells, hyaluronan synthesis was non-significantly but markedly increased, and pro-collagen productions were significantly increased in HDF cells, at all three different concentrations (0.25, 0.75 and 1 mg/ml), and elastase inhibitory activities were observed by PCP treatment. A significant decrease in UVB-induced MMP-1 activity was also observed in 1 mg/ml PCP-treated HDF cells as compared to those of UVB-exposed cells. Conclusions : Taken together, these results suggest that PCP has favorable antioxidant, anti-wrinkle and moisturizing effects without meaningful cytotoxicity on HDF and HaCaT cell lines.
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참고문헌 (73)
참고문헌 신청
Gilchrest BA / 1990 / Skin aging and photoaging / Dermatology nursing 2(2):79~82
Cevenini E / 2008 / Human models of aging and longevity / Expert opinion on biological therapy 8(9):1393~1405
Jurkiewicz BA / 1994 / Ultraviolet light-induced free radical formation in skin: an electron paramagnetic resonance study / Photochemistry and photobiology 59(1):1~4
Messarah M / 2010 / Influence of thyroid dysfunction on liver lipid peroxidation and antioxidant status in experimental rats / Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 62(3):301~310
Rodriguez KJ / 2013 / A purified feverfew extract protects from oxidative damage by inducing DNA repair in skin cells via a PI3-kinase-dependent Nrf2/ARE pathway / Journal of dermatological science 72(3):304~310
Cevenini E / 2008 / Human models of aging and longevity / Expert opinion on biological therapy 8(9):1393~1405
Jurkiewicz BA / 1994 / Ultraviolet light-induced free radical formation in skin: an electron paramagnetic resonance study / Photochemistry and photobiology 59(1):1~4
Messarah M / 2010 / Influence of thyroid dysfunction on liver lipid peroxidation and antioxidant status in experimental rats / Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 62(3):301~310
Rodriguez KJ / 2013 / A purified feverfew extract protects from oxidative damage by inducing DNA repair in skin cells via a PI3-kinase-dependent Nrf2/ARE pathway / Journal of dermatological science 72(3):304~310
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