지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국약제학회 Journal of Pharmaceutical Investigation Journal of Pharmaceutical Investigation 제47권 제6호
- 발행연도
- 2017.11
- 수록면
- 559 - 574 (16page)
이용수
초록· 키워드
오류제보하기
Vitamin E (VE) is highly lipophilic in nature with a very low water solubility which degrades rapidly in presence of oxygen, and free-radical mediated oxidative processes. Spray drying of oil-in-water emulsions containing hydrophilic carriers was used to encapsulate lipophilic compounds into powders. The purpose of this study was to prepare microcapsules of VE using different starch derivatives to increase its stability and to disperse it in aqueous environment. Emulsion of VE acetate was prepared using cremophore RH 40 with tween 80 in a homogenizer and then spray dried. The spray process was optimized using a central composite design for two variables to obtain microcapsules with desirable characteristics.
Microcapsules containing 2, 4 and 6% w/w of VE acetate were produced. The microcapsules were evaluated for their physical, morphological, in vitro release, solid state characterization such as SEM, FTIR, P-XRD and its in vitro free radical scavenging activity. The results showed that obtained microcapsules are nearly spherical in shape with mean particle size of microcapsules were ranged from 1 to 12 lm. The drug content and encapsulation efficiency (53?63%) was found to be uniform and within acceptable range. Optimized formulations were kept for 3 months stability study and found to be stable.
목차
등록된 정보가 없습니다.
참고문헌 (34)
참고문헌 신청
Abayomi M / 2014 / Phytochemical testing and in vitro antibacterial activity of Bixa orellana (Annatto) seed extract / Br J Pharm Res 4:1387~1399
Bae E / 2008 / Microencapsulation of avocado oil by spray drying using whey protein and maltodextrin / J Microencapsul 25:549~560
Baschong W / 2000 / Direct evidence for bioconversion of vitamin E acetate into vitamin E:an ex vivo study in viable human skin / J Cosmet Sci 52:155~161
Basnet P / 2012 / Liposomal delivery system enhances anti-inflammatory properties of curcumin / J Pharm Sci 101:598~609
Chiu Y / 2007 / Encapsulation of lycopene extract from tomato pulp waste with gelatin and poly (c-glutamic acid) as carrier / J Agric Food Chem 55:5123~5130
Bae E / 2008 / Microencapsulation of avocado oil by spray drying using whey protein and maltodextrin / J Microencapsul 25:549~560
Baschong W / 2000 / Direct evidence for bioconversion of vitamin E acetate into vitamin E:an ex vivo study in viable human skin / J Cosmet Sci 52:155~161
Basnet P / 2012 / Liposomal delivery system enhances anti-inflammatory properties of curcumin / J Pharm Sci 101:598~609
Chiu Y / 2007 / Encapsulation of lycopene extract from tomato pulp waste with gelatin and poly (c-glutamic acid) as carrier / J Agric Food Chem 55:5123~5130
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