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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국응용생명화학회 Journal of applied biological chemistry Journal of applied biological chemistry 제62권 제1호
- 발행연도
- 2019.1
- 수록면
- 101 - 107 (7page)
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초록· 키워드
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The objectives of this study were to evaluate the anti-aging effects and investigate the effect of simulated gastrointestinal (GI) digestion on the anti-aging properties and intestinal permeation of the potential fish collagen hydrolysates (FCH). Therefore, procollagen synthesis, matrix metalloproteinase-1 (MMP-1) production, and Caco-2 cell permeability were analyzed before and after in vitro digestion for FCHs, low-molecular weight fractions (<1 kDa), and high molecular weight fractions (>1 kDa). After being subjected to GI digestion, the level of MMP-1 inhibition was maintained, although the procollagen production was significantly (>20%) lower with all samples. Also, the digested FCHs and their <1 kDa fraction yielded 9.1 and 13.8% increased peptide transport, respectively, compared to undigested samples. Based on the effective intestinal permeation and high digestive enzyme stability, the <1 kDa fraction of FCHs is a potential bioactive material suitable for anti-aging applications in the food and cosmetics industries.
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참고문헌 (24)
참고문헌 신청
Gragnani A / 2014 / Review of major theories of skin aging / Adv Aging Res 3:265~284
Brohem CA / 2011 / Artificial skin in perspective : concepts and applications / Pigm Cell Melanoma R 24:35~50
Michel APM / 2013 / In vivo measurement of mid-infrared light scattering from human skin / Biomed Opt Express 4:520~530
Vivian Zague / 2011 / Collagen Hydrolysate Intake Increases Skin Collagen Expression and Suppresses Matrix Metalloproteinase 2 Activity / Journal of Medicinal Food 14(6):618~624
Fisher GJ / 2002 / Mechanisms of photoaging and chronological skin aging / Arch Dermatol 138:1462~1470
Brohem CA / 2011 / Artificial skin in perspective : concepts and applications / Pigm Cell Melanoma R 24:35~50
Michel APM / 2013 / In vivo measurement of mid-infrared light scattering from human skin / Biomed Opt Express 4:520~530
Vivian Zague / 2011 / Collagen Hydrolysate Intake Increases Skin Collagen Expression and Suppresses Matrix Metalloproteinase 2 Activity / Journal of Medicinal Food 14(6):618~624
Fisher GJ / 2002 / Mechanisms of photoaging and chronological skin aging / Arch Dermatol 138:1462~1470
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