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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 291 - 297 (7page)
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초록· 키워드
오류제보하기
Cytisine (CYT), a partial agonist of ${\alpha}4{\beta}2-nicotinic$ receptors, has been used for antidepressant efficacy in several tests. Nicotinic receptors have been shown to be closely associated with depression. However, little is known about the effects of CYT on the depression. In the present study, a mouse model of depression, the unpredictable chronic mild stress (UCMS), was used to evaluate the activities of CYT. UCMS caused significant depression-like behaviors, as shown by the decrease of total distances in open field test, and the prolonged duration of immobility in tail suspension test and forced swimming test. Treatment with CYT for two weeks notably relieved the depression-like behaviors in the UCMS mice. Next, proteins related to depressive disorder in the brain region of hippocampus and amygdala were analyzed to elucidate the underlying mechanisms of CYT. CYT significantly reversed the decreases of 5-HT1A, BDNF, and mTOR levels in the hippocampus and amygdala. These results imply that CYT may act as a potential anti-depressant in the animals under chronic stress.
목차
등록된 정보가 없습니다.
참고문헌 (40)
참고문헌 신청
Abelaira, H. M / 2014 / The role of mTOR in depression and antidepressant responses / Life Sci 101:10~14
Arias, H. R / 2010 / Tricyclic antidepressants and mecamylamine bind to different sites in the human alpha4beta2 nicotinic receptor ion channel / Int. J. Biochem. Cell Biol 42:1007~1018
Bell, R. L / 2009 / Nicotinic receptor ligands reduce ethanol intake by high alcohol-drinking HAD-2 rats / Alcohol 43:581~592
Bergami, M / 2012 / A fight for survival: the challenges faced by a newborn neuron integrating in the adult hippocampus / Dev. Neurobiol 72:1016~1031
Cahill, K / 2013 / Pharmacological interventions for smoking cessation: an overview and network meta-analysis / Cochrane Database Syst. Rev 5:cd009329
Arias, H. R / 2010 / Tricyclic antidepressants and mecamylamine bind to different sites in the human alpha4beta2 nicotinic receptor ion channel / Int. J. Biochem. Cell Biol 42:1007~1018
Bell, R. L / 2009 / Nicotinic receptor ligands reduce ethanol intake by high alcohol-drinking HAD-2 rats / Alcohol 43:581~592
Bergami, M / 2012 / A fight for survival: the challenges faced by a newborn neuron integrating in the adult hippocampus / Dev. Neurobiol 72:1016~1031
Cahill, K / 2013 / Pharmacological interventions for smoking cessation: an overview and network meta-analysis / Cochrane Database Syst. Rev 5:cd009329
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