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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 10 - 17 (8page)
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초록· 키워드
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Objectives: Boswellic acid (BA), a compound isolated from the gum-resin of Boswellia carterii, is a pentacyclic terpenoid that is active against many inflammatory diseases, including cancer, arthritis, chronic colitis, ulcerative colitis, Crohn's disease, and memory impairment, but the mechanism is poorly understood. This study investigated the effects of boswellic acid on spatial learning and memory impairment induced by trimethyltin (TMT) in Wistar rats.
Methods: Forty male Wistar rats were randomly divided into 5 groups: Normal group, TMT-administrated rats (8.0 mg/kg, Intraperitoneally, i.p.) and TMT + BA (40, 80 and 160 mg/kg, i.p.)-administrated rats. BA was used daily for 21 days. To evaluate the cognitive improving of BA, we performed the Morris water maze test. Moreover, to investigate the neuroprotective effect of BA, we determined the acetylcholinesterase (AchE) activity, the malondialdehyde (MDA) level as a marker of lipid peroxidation, and the glutathione (GSH) content in the cerebral cortex.
Results: Treatment with TMT impaired learning and memory, and treatment with BA at a dose of 160 mg/ kg produced a significant improvement in learning and memory abilities in the water maze tasks. Consistent with behavioral data, the activity of AChE was significantly increased in the TMT-injected rats compared to the control group (P < 0.01) whereas all groups treated with BA presented a more significant inhibitory effect against AChE than the TMT-injected animals. In addition, TMT reduced the GSH content and increased the MDA level in the cerebral cortex as compared to the control group) P < 0.01). On the other hand, treatment with BA at 160 mg/kg slightly increased the GSH content and reduced the MDA level in comparison to the TMT-administered group (P < 0.01).
Conclusion: The above results suggest that the effect of BA in improving the cognitive function may be mediated through its antioxidant activity.
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참고문헌 (43)
참고문헌 신청
Razavi M / 2013 / Crocin restores hypotensive effect of subchronic administration of diazinon in rats / Iran J Basic Med Sci 16(1):64~72
Gasso S / 2000 / Trimethyltin and triethyltin differentially induce spontaneous noradrenaline release from rat hippocampal slices / Toxicol Appl Pharmacol 162(3):189~196
Jenkins SM / 2004 / The neurotoxicant trimethyltin induces apoptosis via caspase activation, p38 protein kinase, and oxidative stress in PC12 cells / Toxicol lett 147(1):63~72
Thompson TA / 1996 / Induction of apoptosis by organotin compounds in vitro : neuronal protection with antisense oligonucleotides directed against stannin / J Pharmacol Exp Ther 276(3):1201~1216
Kim JK / 2011 / Effects of methoxsalen from Poncirus trifoliata on acetylcholinesterase and trimethyltin-induced learning and memory impairment / Biosci Biotechnol Biochem 75(10):1984~1989
Gasso S / 2000 / Trimethyltin and triethyltin differentially induce spontaneous noradrenaline release from rat hippocampal slices / Toxicol Appl Pharmacol 162(3):189~196
Jenkins SM / 2004 / The neurotoxicant trimethyltin induces apoptosis via caspase activation, p38 protein kinase, and oxidative stress in PC12 cells / Toxicol lett 147(1):63~72
Thompson TA / 1996 / Induction of apoptosis by organotin compounds in vitro : neuronal protection with antisense oligonucleotides directed against stannin / J Pharmacol Exp Ther 276(3):1201~1216
Kim JK / 2011 / Effects of methoxsalen from Poncirus trifoliata on acetylcholinesterase and trimethyltin-induced learning and memory impairment / Biosci Biotechnol Biochem 75(10):1984~1989
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