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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 157 - 166 (10page)
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Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a common clinical syndrome of diffuse lung inflammation with high mortality rates and limited therapeutic methods. Diosmetin, an active component from Chinese herbs, has long been noticed because of its antioxidant and anti-inflammatory activities. The aim of this study was to evaluate the effects of diosmetin on LPS-induced ALI model and unveil the possible mechanisms. Our results revealed that pretreatment with diosmetin effectively alleviated lung histopathological changes, which were further evaluated by lung injury scores. Diosmetin also decreased lung wet/dry ratios, as well as total protein levels, inflammatory cell infiltration and proinflammatory cytokine (eg. $TNF-{\alpha}$, $IL-1{\beta}$ and IL-6) overproduction in bronchoalveolar lavage fluid (BALF). Additionally, increased MPO, MDA and ROS levels induced by LPS were also markly suppressed by diosmetin. Furthermore, diosmetin significantly increased the expression of Nrf2 along with its target gene HO-1 and blocked the activation of NLRP3 inflammasome in the lung tissues, which might be central to the protective effects of diosmetin. Further supporting these results, in vitro experiments also showed that diosmetin activated Nrf2 and HO-1, as well as inhibited the NLRP3 inflammasome in both RAW264.7 and A549 cells. The present study highlights the protective effects of diosmetin on LPS-induced ALI via activation of Nrf2 and inhibition of NLRP3 inflammasome, bringing up the hope of its application as a therapeutic drug towards LPS-induced ALI.
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참고문헌 (35)
참고문헌 신청
Alam, J. / 1999 / Nrf2, a Cap'n'Collar transcription factor, regulates induction of the heme oxygenase-1 gene / J. Biol. Chem. 274:26071~26078
Androutsopoulos, V. P. / 2009 / Anticancer effects of the flavonoid diosmetin on cell cycle progression and proliferation of MDA-MB 468 breast cancer cells due to CYP1 activation / Oncol. Rep. 21:1525~1528
Baetz, D. / 2005 / Nuclear factor-${\kappa}B$ decoys suppress endotoxin-induced lung injury / Mol. Pharmacol. 67:977~979
Boaru, S. G. / 2015 / NLRP3 inflammasome expression is driven by NF-${\kappa}B$ in cultured hepatocytes / Biochem. Biophys. Res. Commun. 458:700~706
Chabot, F. / 1998 / Reactive oxygen species in acute lung injury / Eur. Respir. J. 11:745~757
Androutsopoulos, V. P. / 2009 / Anticancer effects of the flavonoid diosmetin on cell cycle progression and proliferation of MDA-MB 468 breast cancer cells due to CYP1 activation / Oncol. Rep. 21:1525~1528
Baetz, D. / 2005 / Nuclear factor-
Boaru, S. G. / 2015 / NLRP3 inflammasome expression is driven by NF-
Chabot, F. / 1998 / Reactive oxygen species in acute lung injury / Eur. Respir. J. 11:745~757
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