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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.12
- 수록면
- 237 - 242 (6page)
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초록· 키워드
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Interleukin-1b (IL-1β), a proinflammatory cytokine, regulates the innate immune responses against bacterial infection. Mature IL-1β is produced from pro-IL-1β by activated caspase-1, which in turn is activated by the inflammasome complex formation. In this study, we compared the inflammasome mRNA expression induced by S. sanguinis, S. oralis, F. nucleatum and P. intermedia.
Among the tested bacteria, S. sanguinis induced the highest IL-1β secretion. S. oralis, F. nucleatum and P. intermedia induced very weak IL-1β secretion. S. sanguinis mostly induced the NLRP3 mRNA expressions. Although F.
nucleatum did not induce high IL-1β secretion, it induced high expression levels of AIM2, NLRP2, and NLRP3. No specific inflammasomes were induced by S. oralis and P.intermedia. Studying the inflammasome complex activation induced by oral bacteria may thus enhance our understanding of the pathogenesis of oral diseases.
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등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Charles A. Dinarello / 2009 / Immunological and Inflammatory Functions of the Interleukin-1 Family / Annual Review of Immunology 27(1):519~550
Franchi L ET / 2009 / The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis / Nat Immunol 10:241~247
Beckley K. Davis / 2011 / The Inflammasome NLRs in Immunity, Inflammation, and Associated Diseases / Annual Review of Immunology 29(1):707~735
Petr Broz / 2011 / Molecular mechanisms of inflammasome activation during microbial infections / Immunological Reviews 243(1):174~190
Luigi Franchi / 2012 / NLRC4-driven production of IL-1β discriminates between pathogenic and commensal bacteria and promotes host intestinal defense / Nature Immunology 13(5):449~456
Franchi L ET / 2009 / The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis / Nat Immunol 10:241~247
Beckley K. Davis / 2011 / The Inflammasome NLRs in Immunity, Inflammation, and Associated Diseases / Annual Review of Immunology 29(1):707~735
Petr Broz / 2011 / Molecular mechanisms of inflammasome activation during microbial infections / Immunological Reviews 243(1):174~190
Luigi Franchi / 2012 / NLRC4-driven production of IL-1β discriminates between pathogenic and commensal bacteria and promotes host intestinal defense / Nature Immunology 13(5):449~456
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