지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.10
- 수록면
- 513 - 523 (11page)
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초록· 키워드
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Background: Korean Red Ginseng extracts (RGE) have been suggested as effective immune modulators, and we reported that ginsenosides possess anti-inflammasome properties. However, the properties of nonsaponin components of RGE have not been well studied.
Methods: To assess the roles of nonsaponin fractions (NS) in NLRP3 inflammasome activation, we treated murine macrophages with or without first or second inflammasome activation signals with RGE, NS, or saponin fractions (SF). The first signal was nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB)-mediated transcription of pro-interleukin (IL)-1b and NLRP3 while the second signal triggered assembly of inflammasome components, leading to IL-1b maturation. In addition, we examined the role of NS in IL-6 production and IL-1b maturation in mice.
Results: NS induced IL-1b and NLRP3 transcription via toll-like receptor 4 signaling, whereas SF blocked expression. During the second signal, SF attenuated NLRP3 inflammasome activation while NS did not. Further, NS-injected mice presented increased IL-1b maturation and IL-6 production.
Conclusion: SF and NS of RGE play differential roles in the NLRP3 inflammasome activation. Hence, RGE can be suggested as an NLRP3 inflammasome modulator.
Methods: To assess the roles of nonsaponin fractions (NS) in NLRP3 inflammasome activation, we treated murine macrophages with or without first or second inflammasome activation signals with RGE, NS, or saponin fractions (SF). The first signal was nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB)-mediated transcription of pro-interleukin (IL)-1b and NLRP3 while the second signal triggered assembly of inflammasome components, leading to IL-1b maturation. In addition, we examined the role of NS in IL-6 production and IL-1b maturation in mice.
Results: NS induced IL-1b and NLRP3 transcription via toll-like receptor 4 signaling, whereas SF blocked expression. During the second signal, SF attenuated NLRP3 inflammasome activation while NS did not. Further, NS-injected mice presented increased IL-1b maturation and IL-6 production.
Conclusion: SF and NS of RGE play differential roles in the NLRP3 inflammasome activation. Hence, RGE can be suggested as an NLRP3 inflammasome modulator.
목차
ABSTRACT
1. Introduction
2. Materials and methods
3. Results
4. Discussion
References
참고문헌 (34)
참고문헌 신청
[학술지(정기간행물)] - 강수원 / 2012 / Ginseng, the 'Immunity Boost': The Effects of Panax ginseng on Immune System / Journal of Ginseng Research 36 (4) : 354 ~ 368
[학술지(정기간행물)] - Ru W / 2015 / Chemical constituents and bioactivities of Panax ginseng (C. A. Mey.) / Drug Discov Ther 9 : 23 ~ 32
[학술지(정기간행물)] - Seung-Hoon Baek / 2012 / Recent Methodology in Ginseng Analysis / Journal of Ginseng Research 36 (2) : 119 ~ 134
[학술지(정기간행물)] - 손은화 / 2011 / Effects of Korean Red Ginseng Extract for the Treatment of Atopic Dermatitis-Like Skin Lesions in Mice / Journal of Ginseng Research 35 (4) : 479 ~ 486
[학술지(정기간행물)] - Lu JM / 2009 / Ginseng compounds : an update on their molecular mechanisms and medical applications / Curr Vasc Pharmacol 7 : 293 ~ 302
[학술지(정기간행물)] - Ru W / 2015 / Chemical constituents and bioactivities of Panax ginseng (C. A. Mey.) / Drug Discov Ther 9 : 23 ~ 32
[학술지(정기간행물)] - Seung-Hoon Baek / 2012 / Recent Methodology in Ginseng Analysis / Journal of Ginseng Research 36 (2) : 119 ~ 134
[학술지(정기간행물)] - 손은화 / 2011 / Effects of Korean Red Ginseng Extract for the Treatment of Atopic Dermatitis-Like Skin Lesions in Mice / Journal of Ginseng Research 35 (4) : 479 ~ 486
[학술지(정기간행물)] - Lu JM / 2009 / Ginseng compounds : an update on their molecular mechanisms and medical applications / Curr Vasc Pharmacol 7 : 293 ~ 302
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UCI(KEPA) : I410-ECN-0101-2018-524-001599271