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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 158 - 164 (7page)
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Methylglyoxal (MGO) is a highly reactive metabolite of glucose which is known to cause damage and induce apoptosis in endothelial cells. Endothelial cell damage is implicated in the progression of diabetes-associated complications and atherosclerosis. Hypericin, a naphthodianthrone isolated from Hypericum perforatum L. (St. John's Wort), is a potent and selective inhibitor of protein kinase C and is reported to reduce neuropathic pain. In this work, we investigated the protective effect of hypericin on MGO-induced apoptosis in human umbilical vein endothelial cells (HUVECs). Hypericin showed significant anti-apoptotic activity in MGO-treated HUVECs. Pretreatment with hypericin significantly inhibited MGO-induced changes in cell morphology, cell death, and production of intracellular reactive oxygen species. Hypericin prevented MGO-induced apoptosis in HUVECs by increasing Bcl-2 expression and decreasing Bax expression. MGO was found to activate mitogen-activated protein kinases (MAPKs). Pretreatment with hypericin strongly inhibited the activation of MAPKs, including P38, JNK, and ERK1/2. Interestingly, hypericin also inhibited the formation of AGEs. These findings suggest that hypericin may be an effective regulator of MGO-induced apoptosis. In conclusion, hypericin downregulated the formation of AGEs and ameliorated MGO-induced dysfunction in human endothelial cells.
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참고문헌 (42)
참고문헌 신청
Akhand, A. A. / 2001 / Glyoxal and methylglyoxal trigger distinct signals for map family kinases and caspase activation in human endothelial cells / Free Radic. Biol. Med 31:20~30
Biswas, S. / 2002 / Passive cigarette smoke and the renal glyoxalase system / Mol. Cell. Biochem 229:153~156
Bourajjaj, M. / 2003 / Role of methylglyoxal adducts in the development of vascular complications in diabetes mellitus / Biochem. Soc. Trans 31:1400~1402
Caccia, S. / 2005 / Antidepressant-like components of Hypericum perforatum extracts: an overview of their pharmacokinetics and metabolism / Curr. Drug Metab 6:531~543
Cakir, A. / 2003 / Isolation and characterization of antioxidant phenolic compounds from the aerial parts of Hypericum hyssopifolium L. by activity-guided fractionation / J. Ethnopharmacol 87:73~83
Biswas, S. / 2002 / Passive cigarette smoke and the renal glyoxalase system / Mol. Cell. Biochem 229:153~156
Bourajjaj, M. / 2003 / Role of methylglyoxal adducts in the development of vascular complications in diabetes mellitus / Biochem. Soc. Trans 31:1400~1402
Caccia, S. / 2005 / Antidepressant-like components of Hypericum perforatum extracts: an overview of their pharmacokinetics and metabolism / Curr. Drug Metab 6:531~543
Cakir, A. / 2003 / Isolation and characterization of antioxidant phenolic compounds from the aerial parts of Hypericum hyssopifolium L. by activity-guided fractionation / J. Ethnopharmacol 87:73~83
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