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- 대한악안면성형재건외과학회 Maxillofacial Plastic Reconstructive Surgery Maxillofacial Plastic Reconstructive Surgery 제42권 제6호
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- 2020.1
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Background4-Hexylresorcinol (4HR) is able to increase angiogenesis. However, its molecular mechanism in the human endothelial cells has not been clarified. MethodsAs endothelial cells are important in angiogenesis, we treated the human umbilical vein endothelial cells (HUVECs) with 4HR and investigated protein expressional changes by immunoprecipitation high-performance liquid chromatography (IP-HPLC) using 96 antisera. ResultsHere, we found that 4HR upregulated transforming growth factor-β (TGF-β)/SMAD/vascular endothelial growth factor (VEGF) signaling, RAF-B/ERK and p38 signaling, and M2 macrophage polarization pathways. 4HR also increased expression of caspases and subsequent cellular apoptosis. Mechanistically, 4HR increased TGF-β1 production and subsequent activation of SMADs/VEGFs, RAF-B/ERK and p38 signaling, and M2 macrophage polarization. ConclusionCollectively, 4HR activates TGF-β/SMAD/VEGF signaling in endothelial cells and induced vascular regeneration and remodeling for wound healing.
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참고문헌 (30)
참고문헌 신청
McConnell VF / 1953 / Hlasiwetz and Barth-pioneers in the structural aspects of plant products / J Chem Educ 30:380~385
Wilson CO / 1966 / Textbook of organic medicinal and pharmaceutical chemistry / Lippincott :237~262
He J / 2017 / Oxyresveratrol and ascorbic acid O/W microemulsion : preparation, characterization, antiisomerization and potential application as antibrowning agent on fresh-cut lotus root slices / Food Chem 214:269~276
Darlow HM / 1958 / Observations on the bactericidal action of hexyl resorcinol aerosols / J Hyg 56:108~124
Brkic D / 1956 / Intestinal parasites : helminths; with special reference to newer antihelminthics / Srp Arh Celok Lek 84:1401~1416
Wilson CO / 1966 / Textbook of organic medicinal and pharmaceutical chemistry / Lippincott :237~262
He J / 2017 / Oxyresveratrol and ascorbic acid O/W microemulsion : preparation, characterization, antiisomerization and potential application as antibrowning agent on fresh-cut lotus root slices / Food Chem 214:269~276
Darlow HM / 1958 / Observations on the bactericidal action of hexyl resorcinol aerosols / J Hyg 56:108~124
Brkic D / 1956 / Intestinal parasites : helminths; with special reference to newer antihelminthics / Srp Arh Celok Lek 84:1401~1416
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