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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.6
- 수록면
- 99 - 114 (16page)
- DOI
- 10.20307/nps.2021.27.2.99
이용수
초록· 키워드
오류제보하기
Type 2 diabetes mellitus (T2DM) and its complications are important noncommunicable diseases with high mortality rates. Protein tyrosine phosphatase 1B (PTP1B) and aldose reductase inhibitors are recently approached and advanced for T2DM and its complications therapy. Matricaria chamomilla L. is acknowledged as a worldwide medicinal herb that has many beneficial health effects as well as antidiabetic effects. Our research was designed to determine the most potential antidiabetic phytochemicals from M. chamomilla employing in silico study. 142 phytochemicals were obtained from the databases. The first screening employed iGEMdock and Swiss ADME, involving 93 phytochemicals. Finally, 30 best phytochemicals were docked. Molecular docking and visualization analysis were performed using Avogadro, AutoDock 4.2., and Biovia Discovery Studio 2016. Molecular docking results demonstrate that ligand-protein interaction"s binding affinities were -5.16 to -7.54 kcal/mol and -5.30 to -12.10 kcal/mol for PTP1B and aldose reductase protein targets respectively. In silico results demonstrate that M. chamomilla has potential antidiabetic phytochemical compounds for T2DM and its complications. We recommended anthecotulide, quercetin, chlorogenic acid, luteolin, and catechin as antidiabetic agents due to their binding affinities against both PTP1B and aldose reductase protein. Those phytochemicals" significant efficacy and potential as antidiabetic must be investigated in further advanced research.
목차
Abstract
Introduction
Experimental
Results and Discussion
References
참고문헌 (51)
참고문헌 신청
International Diabetes Federation / 2017 / IDF DIABETES ATLAS vol. 8th Edition / International Diabetes Federation :14~95
American Diabetes Association / 2019 / Diabetes Care: Standards of Medical Care in Diabetes :S13~S28
Halim, M. / 2019 / Diabetes Metab. Syndr. 13:1165~1172
Brownlee, M. / 2005 / Diabetes 54:1615~1625
Dowarah, J. / 2020 / Bioorg. Med. Chem 28:115263
American Diabetes Association / 2019 / Diabetes Care: Standards of Medical Care in Diabetes :S13~S28
Halim, M. / 2019 / Diabetes Metab. Syndr. 13:1165~1172
Brownlee, M. / 2005 / Diabetes 54:1615~1625
Dowarah, J. / 2020 / Bioorg. Med. Chem 28:115263
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