지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 171 - 177 (7page)
이용수
초록· 키워드
오류제보하기
Appetite is inhibited by the anorexigenic neuropeptides POMC (proopiomelanocortin) and CART (cocaine-amphetamine-regulated transcript) in the hypothalamus. The present study was performed to examine the inhibitory effects of baicalin against food intake and the upregulation of POMC/CART. Short-term food intake (48 h) was significantly inhibited by treatment with baicalin (10 mg/kg, p<0.05) in C57BL/6 mice. Immunohistochemical analysis showed that baicalin upregulated POMC and CART levels in the arcuate nucleus of the hypothalamus. These effects were also examined using an in vitro system. pPOMC-Luc or pCART-Luc plasmids were transformed into mouse N29-2 neuronal and human SH-SY5Y cells, and the activities of baicalin were examined in these cells. Baicalin increased POMC and CART promoter-driven luciferase activity in a dose-dependent manner without cytotoxic effects. These results suggest that baicalin downregulates short-term food intake while upregulating POMC and CART expression.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Baicalin이 조골세포의 생성 및 활성에 미치는 영향
Journal of Oral Medicine and Pain
2008 .06
-
Baicalin이 3T3-L1 세포의 분화에 미치는 영향
약학회지
1994 .01
-
알코올성 지방간에서 Baicalin의 허혈 및 재관류로 인한 간 손상 보호 효과
약학회지
2012 .01
-
Effects of Baicalin on Oral Pharmacokinetics of Caffeine in Rats
Biomolecules & Therapeutics(구 응용약물학회지)
2015 .01
-
Role of metabolism by intestinal microbiota in pharmacokinetics of oral baicalin
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2014 .01
-
The Role of Intestinal Microflora in Anti-Inflammatory Effect of Baicalin in Mice
Biomolecules & Therapeutics(구 응용약물학회지)
2012 .01
-
Baicalin을 처리한 HL-60 백혈병 세포주에서 대규모 유전자 분석 발현 연구
동의생리병리학회지
2004 .10
-
면역결핍바이러스 인테그라제 억제제로서 Baicalein과 Baicalin
약학회지
2003 .01
-
Baicalin Induces Apoptosis in Leukemia HL-60/ADR Cells via Possible Down-regulation of the PI3K/Akt Signaling Pathway
Asian Pacific journal of cancer prevention : APJCP
2012 .01
-
Metabolism of glycyrrhizin and baicalin by human intestinal bacteria
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
1996 .01
-
Baicalin attenuates lipopolysaccharide-induced neuroinflammation in cerebral cortex of mice via inhibiting NF-κB activation
한국실험동물학회 학술발표대회 논문집
2019 .07
-
흰쥐의 일차배양 간세포에서 Glycyrrhizin 및 Baicalin의 간 보호 활성 평가
약학회지
2006 .01
-
The Molecular Mechanism of Baicalin on RANKL-induced Osteoclastogenesis in RAW264.7 Cells
International Journal of Oral Biology
2013 .01
-
Effects of Baicalin on the acute liver and kidney injury induced by hepatic ischemia/reperfusion in rats
한국실험동물학회 학술발표대회 논문집
2013 .02
-
Studies on Gene Expression of baicalin treated in HL-60 cell line using High-throughput Gene Expression Analysis Techniques
대한동의병리학회 학술대회논문집
2004 .08
-
Baicalin protects adults mouse brain against LPS-induced oxidative stress-mediated neuroinflammation and neurodegeneration
한국실험동물학회 학술발표대회 논문집
2018 .07
-
Effects of Baicalin on the differentiation and activity of preosteoclasts
International Journal of Oral Biology
2009 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0