지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 36 - 42 (7page)
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Baicalin, a main constituent of the rhizome of Scutellaria baicalensis, is metabolized to baicalein and oroxylin A in the intestine before its absorption. To understand the role of intestinal microflora in the pharmacological activities of baicalin, we investigated its anti-inflammatory effect in mice treated with and without antibiotics. Orally administered baicalin showed the anti-inflammatory effect in mice than intraperitoneally treated one, apart from intraperitoneally administered its metabolites, baicalein and oroxylin A, which potently inhibited LPS-induced inflammation. Of these metabolites, oroxylin A showed more potent anti-inflammatory effect. However, treatment with the mixture of cefadroxil, oxytetracycline and erythromycin (COE) significantly attenuated the anti-inflammatory effect of orally administered baicalin in mice. Treatment with COE also reduced intestinal bacterial fecal ${\beta}$-glucuronidase activity. The metabolic activity of human stools is significantly different between individuals, but neither between ages nor between male and female. Baicalin was metabolized to baicalein and oroxylin A, with metabolic activities of $1.427{\pm}0.818$ and $1.025{\pm}0.603$ pmol/min/mg wet weight, respectively. Baicalin and its metabolites also inhibited the expression of pro-inflammatory cytokines, TNF-${\alpha}$ and IL-$1{\beta}$, and the activation of NF-${\kappa}B$B in LPS-stimulated peritoneal macrophages. Of them, oroxylin A showed the most potent inhibition. Based on these findings, baicalin may be metabolized to baicalein and oroxylin A by intestinal microflora, which enhance its anti-inflammatory effect by inhibiting NF-${\kappa}B$ activation.
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참고문헌 (33)
참고문헌 신청
Abe, K. / 1990 / Biliary excretion of metabolites of baicalin and baicalein in rats / Chem. Pharm. Bull. (Tokyo) 38:209~211
Akao, T. / 1988 / Intestinal bacterial hydrolysis is required for the appearance of compound K in rat plasma after oral administration of ginsenoside Rb1 from Panax ginseng / J. Pharm. Pharmacol 50:1155~1160
Akao, T. / 1988 / Appearance of compound K, a major metabolite of ginsenoside Rb1 by intestinal bacteria, in rat plasma after oral administration--measurement of compound K by enzyme immunoassay / Biol. Pharm. Bull 21:245~249
Akao, T. / 2004 / Enteric excretion of baicalein, a fl avone of Scutellariae Radix, via glucuronidation in rat: involvement of multidrug resistance-associated protein 2 / Pharm. Res 21:2120~2126
Akao, T. / 2000 / Baicalin, the predominant fl avone glucuronide of scutellariae radix, is absorbed from the rat gastrointestinal tract as the aglycone and restored to its original form / J. Pharm. Pharmacol 52:1563~1568
Akao, T. / 1988 / Intestinal bacterial hydrolysis is required for the appearance of compound K in rat plasma after oral administration of ginsenoside Rb1 from Panax ginseng / J. Pharm. Pharmacol 50:1155~1160
Akao, T. / 1988 / Appearance of compound K, a major metabolite of ginsenoside Rb1 by intestinal bacteria, in rat plasma after oral administration--measurement of compound K by enzyme immunoassay / Biol. Pharm. Bull 21:245~249
Akao, T. / 2004 / Enteric excretion of baicalein, a fl avone of Scutellariae Radix, via glucuronidation in rat: involvement of multidrug resistance-associated protein 2 / Pharm. Res 21:2120~2126
Akao, T. / 2000 / Baicalin, the predominant fl avone glucuronide of scutellariae radix, is absorbed from the rat gastrointestinal tract as the aglycone and restored to its original form / J. Pharm. Pharmacol 52:1563~1568
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