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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 67 - 72 (6page)
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This study examined the anti-osteoclastogenic effects of baicalin on receptor activator of NF-kB ligand (RANKL)-induced RAW264.7 cells. Baicalin is a flavonoid that is produced by Scutellaria baicalensis and is known to have multiple biological properties, including antibacterial, antiinflammatory and analgesic effects. The effects of baicalin on osteoclasts were examined by measuring 1) cell viability;2) the formation of tartrate-resistant acid phosphatase (TRAP) (+) multinucleated cells; 3) RANK/RANKL signaling pathways and 4) mRNA levels of osteoclast-associated genes. Baicalin inhibited the formation of RANKL-stimulated TRAP (+) multinucleated cells and also suppressed the RANKL-stimulated activation of p-38, ERK, cSrc and AKT signaling. Baicalin also inhibited the RANKL-stimulated degradation of IĸB in RAW264.7 cells. In addition,the RANKL-stimulated induction of NFATc1 transcription factors was found to be abrogated by this flavonoid. Baicalin was further found to decrease the mRNA expression of osteoclast-associated genes, including carbonic anhydrase II, TRAP and cathepsin K in the RAW264.7 cells. Our data thus demonstrate that baicalin inhibits osteoclastogenesis by inhibiting the RANKL-induced activation of signaling molecules and transcription factors in osteoclast precursors.
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참고문헌 (25)
참고문헌 신청
Bodet C / 2008 / Potential oral health benefits of cranberry / Crit Rev Food Sci Nutr 48 : 672 ~ 680
Cazarolli LH / 2008 / Flavonoids: prospective drug candidates / Mini Rev Med Chem 8 : 1429 ~ 1440
Chen AY / 2013 / A review of the dietary flavonoid, kaempferol on human health and cancer chemoprevention / Food Chem 138 : 2099 ~ 2107
Findlay DM / 2005 / Mechanisms of bone loss in rheumatoid arthritis / Mod Rheumatol 15 : 232 ~ 240
Gass M / 2006 / Preventing osteoporosisrelated fractures: an overview / Am J Med 119 : S3 ~ S11
Cazarolli LH / 2008 / Flavonoids: prospective drug candidates / Mini Rev Med Chem 8 : 1429 ~ 1440
Chen AY / 2013 / A review of the dietary flavonoid, kaempferol on human health and cancer chemoprevention / Food Chem 138 : 2099 ~ 2107
Findlay DM / 2005 / Mechanisms of bone loss in rheumatoid arthritis / Mod Rheumatol 15 : 232 ~ 240
Gass M / 2006 / Preventing osteoporosisrelated fractures: an overview / Am J Med 119 : S3 ~ S11
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