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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 81 - 86 (6page)
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초록· 키워드
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Baicalin is a flavonoid purified from the medicinal plant
Scutellaria baicalensis. It has been reported that baicalin
exhibits antibacterial, anti-inflammatory and analgesic
effects. The present study was undertaken to determine the
underlying cellular mechanisms of baicalin action in
preosteoclasts. The effects of this flavonoid on preosteoclasts
were determined by measuring osteoclast generation and
osteoclast activity in macrophage-colony stimulating factor
(M-CSF)-dependent bone marrow cells (MDBMCs) and in
co-cultures of MDBMCs and osteoblasts. Osteoclast
generation was assayed by measuring the number of tartrateresistant
acid phosphatase (TRAP) (+) multinucleated cells
after culture. Osteoclast activity was assayed by measuring
the area of the resorption pit after culture. We found that
osteoclast generation was induced by M-CSF and receptor
activator of NF-kB ligand (RANKL), and by the 1.25-
dihydroxycholecalciferol in our cultures. Baicalin decreased
both osteoclast generation and activity in MDBM cultures
and co-cultures indicating that it may inhibit bone resorption.
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등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Cai X / 2008a / Protective effects of baicalin on ligature-induced periodontitis in rats / J Periodontal Res 43 : 14 ~ 21
Cai X / 2008b / Protective effect of baicalin on experimental periodontitis in rats and its possible mechanisms / Zhonghua Kou Qiang Yi Xue Za Zhi 43 : 281 ~ 285
Chen KM / 2004 / The serum of rats administered flavonoid extract from Epimedium sagittatum but not the extract itself enhances the development of rat calvarial osteoblast-li
Do SH / 2008 / Bone-protecting effect of Rubus coreanus by dual regulation of osteoblasts and osteoclasts / Menopause 15 : 676 ~ 683
Gao Z / 1999 / Free radical scavenging and antioxidant activities of flavonoids extracted from the radix of Scutellaria baicalensis Georgi / Biochim Biophys Acta 1472 : 643 ~
Cai X / 2008b / Protective effect of baicalin on experimental periodontitis in rats and its possible mechanisms / Zhonghua Kou Qiang Yi Xue Za Zhi 43 : 281 ~ 285
Chen KM / 2004 / The serum of rats administered flavonoid extract from Epimedium sagittatum but not the extract itself enhances the development of rat calvarial osteoblast-li
Do SH / 2008 / Bone-protecting effect of Rubus coreanus by dual regulation of osteoblasts and osteoclasts / Menopause 15 : 676 ~ 683
Gao Z / 1999 / Free radical scavenging and antioxidant activities of flavonoids extracted from the radix of Scutellaria baicalensis Georgi / Biochim Biophys Acta 1472 : 643 ~
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Baicalin이 조골세포의 생성 및 활성에 미치는 영향
Journal of Oral Medicine and Pain
2008 .06
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The Molecular Mechanism of Baicalin on RANKL-induced Osteoclastogenesis in RAW264.7 Cells
International Journal of Oral Biology
2013 .01
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A2B Adenosine Receptor Stimulation Down-regulates M-CSF-mediated Osteoclast Proliferation
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RANK Signaling Pathways and Key Molecules Inducing Osteoclast Differentiation
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2017 .12
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Effects of Interleukin-1b, Tumor Necrosis Factor-a and Interferon-g on the Nitric Oxide Production and Osteoclast Generation in the Culture of Mouse Bone Marrow Cells
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2006 .01
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Anti-Osteoclast Therapy in Bone Disease
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2005 .01
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소청룡탕이 파골세포 분화억제와 골흡수에 미치는 영향
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2017 .09
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Osteoclast Activity and Osteoporosis
한국응용약물학회 춘계학술발표논문집
2001 .01
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Baicalin이 3T3-L1 세포의 분화에 미치는 영향
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녹제초 추출물이 파골세포 분화 및 골 흡수에 미치는 영향
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cAMP-response Element-binding Protein Is not Essential for Osteoclastogenesis Induced by Receptor Activator of NF-κB Ligand
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파골세포에 대한 커큐민의 효과
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Extracts of Flavoparmelia sp. Inhibit Receptor Activator of Nuclear Factor-κB Ligand-Mediated Osteoclast Differentiation
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Gene Profiling in Osteoclast Precursors by RANKL Using Microarray
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2013 .06
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Propofol promotes osteoclastic bone resorption by increasing DC-STAMP expression
Journal of dental anesthesia and pain medicine
2018 .01
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Attenuation of RANKL-induced Osteoclast Formation via p38-mediated NFATc1 Signaling Pathways by Extract of Euphorbia Lathyris L
대한골대사학회지
2016 .01
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Molecular Mechanism of Life and Death of the Osteoclast
International Journal of Oral Biology
2004 .01
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알코올성 지방간에서 Baicalin의 허혈 및 재관류로 인한 간 손상 보호 효과
약학회지
2012 .01
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