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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 21 - 27 (7page)
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Clotrimazole (CLT), a potent antifungal drug, is known to inhibit tumor cell proliferation. In the present study, we examined the role of intracellular $Ca^{2+}$ in CLT-induced cell cycle arrest of colon adenocarcinoma HT29 cells. CLT inhibited growth of HT29 cells in a concentration-dependent manner, which was associated with inhibition of cell cycle progression at the G(1)-S phase transition and an increase in the expression of cell cycle inhibitor proteins p27 and p53. CLT also suppressed the $Ca^{2+}$ overload by A23187, a calcium ionophore, suggesting its role in modulation of intracellular $Ca^{2+}$ concentration in HT29 cells. The simultaneous application of CLT and A23187 with addition of $CaCl_2$ (1mM) to the medium significantly reversed CLT-induced p27 and p53 protein level increase and growth suppression. Our results suggest that CLT induces cell cycle arrest of colon adenocarcinoma HT29 cells via induction of p27 and p53, which may, at least in part, be mediated by alteration of intracellular $Ca^{2+}$ level.
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참고문헌 (23)
참고문헌 신청
Aktas, H / 1998 / Depletion of intracellular Ca2+ stores, phosphorylation of eIF2alpha, and sustained inhibition of translation initiation mediate the anticancer effects of CLT / Proc Natl Acad Sci U S A 95(14):8280~8285
Apati, A / 2003 / Calcium induces cell survival and proliferation through the activation of the MAPK pathway in a human hormone-dependent leukemia cell line, TF-1 / J Biol Chem 278(11):9235~9243
Benzaquen, L.R / 1995 / CLT inhibits cell proliferation in vitro and in vivo / Nat Med 1(6):534~540
Berridge,M.J / 1995 / Calcium signalling and cell proliferation / BioEssays 17:491~500
Berridge, M.J / 2000 / The versatility and universality of calcium signalling / Nat Rev Mol Cell Biol 1(1):11~21
Apati, A / 2003 / Calcium induces cell survival and proliferation through the activation of the MAPK pathway in a human hormone-dependent leukemia cell line, TF-1 / J Biol Chem 278(11):9235~9243
Benzaquen, L.R / 1995 / CLT inhibits cell proliferation in vitro and in vivo / Nat Med 1(6):534~540
Berridge,M.J / 1995 / Calcium signalling and cell proliferation / BioEssays 17:491~500
Berridge, M.J / 2000 / The versatility and universality of calcium signalling / Nat Rev Mol Cell Biol 1(1):11~21
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