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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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초록· 키워드
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Cell proliferation is governed by precise and orderly process the regulation of which involves many different proteins. The key enzyme for cell growth and arrest is cyclin dependent kinases (cdks). In human cells, several cdks orchestrate four distinct cell cycle phases (M, G₁, S and G₂) and they sequentially operate in an order of cdc1, cdk4, cdk6 and cdk2. The regulatory components of cdks consist of cyclins and two family of cdk inhibitors, INK4 (inhibitors of cdk4) and KIP (kinase inhibitor protein). G1 regulatory molecules for cdk mainly respond to environmental cues of mitogenic and anti-mitogenic stimuli and therefore influence activities of G1 cdks, namely, cdk4/6 and cdk2. G₁ inhibitors include p21<SUP>CIP</SUP> and p27<SUP>KIP1</SUP>. Between them, p27<SUP>KIP1</SUP> has attracted attentions of many researchers because of its characteristic regulatory features and diverse functions. Besides, the role of p27<SUP>KIP1</SUP> in cancer development warrants further studies in the future. Therefore, this review will focus on the recent findings and especially on the complexity of regulatory mechanisms of p27<SUP>KIP1</SUP>.
목차
Binding of cell cycle inhibitors to cdk complexes
Posttranslational modification determines the function
Localization by phosphorylation status
Deregulation in cancer
Acknowledgements
REFERENCES
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UCI(KEPA) : I410-ECN-0101-2010-510-002463769