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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제31권 제9호
- 발행연도
- 2008.1
- 수록면
- 1,115 - 1,119 (5page)
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초록· 키워드
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We investigated the hepatic effects of daidzein on the 7,12-dimethylbenz(a)anthracene (DMBA)-induced enzymatic activity and expression of CYP1A1 and CYP1B1 in mice. Daidzein was administered orally to mice at 5 or 25 mg/kg BW for three weeks, after which DMBA (34 mg/kg BW) was administered intragastrically twice a week for two weeks. Twenty-four hours after the last DMBA treatment, the mice were sacrificed. DMBA induced CYP1 activity as well as the expression of CYP1A1 and CYP1B1. The catalytic activity of CYP1 enzymes was determined as 7-ethoxyresorufin-O-deethylase (EROD) activity. Each of these effects was significantly reduced by daidzein; however, the reduction was more pronounced for CYP1A1. Daidzein also exerted a negative effect on the transcription of CYP1A1 by AhR, similar to its effect on CYP1A1. The AhR-dependent inhibition of CYP1 by daidzein may explain the anticancer effects of daidzein.
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