지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Objectives: Most drug interactions are attributed to the inhibition or induction of the activity of cytochrome P450s (CYP450). Although the regulation of CYP450s by drugs has been widely reported, there have been few studies on influence of traditional herbal formulas on the drug-metabolizing enzymes. Because herbal formulas have been used traditionally to treat various diseases and because herb-drug interactions are crucial factors determining therapeutic efficacies, a systematic evaluation of the effects of herbal formulas is important.
Methods: The effects of Galgeun-tang (GGT, gegen tang), Gumiganghwal-tang (GMGHT, jiuweiqianghuo tang), Insampaedok-san (ISPDS, renshenbaidu powder), Samsoeum (SSE, shensu drink), Socheongryong-tang (SCRT, xiaoqinglong-tang) and Sosiho-tang (SSHT, xiaochaihu tang) that are traditional herbal formulas used to treat common cold, on drug-metabolizing enzymes were evaluated through an in vitro CYP3A4, CYP2D6, CYP2C19 and CYP2E1 inhibition assay to assess its interaction potential with synthetic drugs. The inhibitory effects of herbal formulas were characterized with IC<SUB>50</SUB> values.
Results: These six herbal formulas inhibited the activities of CYP3A4, 2C19, 2D6 and 2E1, in a concentrationdependent manner. Among the six herbal formulas, GGT critically inhibited CYP2C19, CYP2D6 and CYP2E1. GMGHT also inhibited CYP2D6 and CYP2E1 to a greater extent than the other CYP450 isozymes. Additionally, SSE and SSHT may change the effects of medicines that depend primarily on the CYP2C19 and CYP2E1 pathways. On the other hand, ISPDS and SCRT were not inhibited CYP3A4, CYP2C19, CYP2D6 and CYP2E1-mediated metabolism.
Conclusions: These findings provide useful information regarding the safety and effectiveness of herbal formulas.
Methods: The effects of Galgeun-tang (GGT, gegen tang), Gumiganghwal-tang (GMGHT, jiuweiqianghuo tang), Insampaedok-san (ISPDS, renshenbaidu powder), Samsoeum (SSE, shensu drink), Socheongryong-tang (SCRT, xiaoqinglong-tang) and Sosiho-tang (SSHT, xiaochaihu tang) that are traditional herbal formulas used to treat common cold, on drug-metabolizing enzymes were evaluated through an in vitro CYP3A4, CYP2D6, CYP2C19 and CYP2E1 inhibition assay to assess its interaction potential with synthetic drugs. The inhibitory effects of herbal formulas were characterized with IC<SUB>50</SUB> values.
Results: These six herbal formulas inhibited the activities of CYP3A4, 2C19, 2D6 and 2E1, in a concentrationdependent manner. Among the six herbal formulas, GGT critically inhibited CYP2C19, CYP2D6 and CYP2E1. GMGHT also inhibited CYP2D6 and CYP2E1 to a greater extent than the other CYP450 isozymes. Additionally, SSE and SSHT may change the effects of medicines that depend primarily on the CYP2C19 and CYP2E1 pathways. On the other hand, ISPDS and SCRT were not inhibited CYP3A4, CYP2C19, CYP2D6 and CYP2E1-mediated metabolism.
Conclusions: These findings provide useful information regarding the safety and effectiveness of herbal formulas.
목차
Introduction
Materials and methods
Results
Discussion
Conclusions
References
참고문헌 (36)
참고문헌 신청
1. [학술지(정기간행물)] - Watkins PB / 1992 / Drug metabolism by cytochromes P450 in the liver and small bowel / Gastroenterol Clin North Am 21 (3) : 51126 ~
2. [학술지(정기간행물)] - Hellum BH / 2007 / The induction of CYP1A2, CYP2D6 and CYP3A4 by six trade herbal products in cultured primary human hepatocytes / Basic Clin Pharmacol Toxicol 100 (1) : 2330 ~
3. [학술지(정기간행물)] - Liu R / 2011 / Effects of Panax notoginseng saponins on the activities of CYP1A2, CYP2C9, CYP2D6 and CYP3A4 in rats in vivo / Phytotherapy Res 26 (8) : 11138 ~
4. [학술지(정기간행물)] - 서창섭 / 2008 / 전탕 전과 후의 중금속, 잔류농약 및 잔류이산화황의 농도변화 - 감기약을 중심으로 - / 대한본초학회지 23 (4) : 51 ~ 58
5. [학술지(정기간행물)] - Yang TK / 2002 / An experimental study on the anti-allergic effects, anti-inflammatory action, anti-pyretic action and analgesic action of Galgeun-tang, Gamigalgeun-tang and Geomahwanggalgeun-ang / J Korean Oriental Med Ophthalmol tolaryngol Dermatol 15 (1) : 7695 ~
2. [학술지(정기간행물)] - Hellum BH / 2007 / The induction of CYP1A2, CYP2D6 and CYP3A4 by six trade herbal products in cultured primary human hepatocytes / Basic Clin Pharmacol Toxicol 100 (1) : 2330 ~
3. [학술지(정기간행물)] - Liu R / 2011 / Effects of Panax notoginseng saponins on the activities of CYP1A2, CYP2C9, CYP2D6 and CYP3A4 in rats in vivo / Phytotherapy Res 26 (8) : 11138 ~
4. [학술지(정기간행물)] - 서창섭 / 2008 / 전탕 전과 후의 중금속, 잔류농약 및 잔류이산화황의 농도변화 - 감기약을 중심으로 - / 대한본초학회지 23 (4) : 51 ~ 58
5. [학술지(정기간행물)] - Yang TK / 2002 / An experimental study on the anti-allergic effects, anti-inflammatory action, anti-pyretic action and analgesic action of Galgeun-tang, Gamigalgeun-tang and Geomahwanggalgeun-ang / J Korean Oriental Med Ophthalmol tolaryngol Dermatol 15 (1) : 7695 ~
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UCI(KEPA) : I410-ECN-0101-2015-510-002490853