지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 1,113 - 1,119 (7page)
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Purpose: The cytochrome P450 2C19 (CYP2C19) metabolizes arachidonic acid to produce epoxyicosanoid acids, which are involved in vascular tone and regulation of blood pressure. Recent findings suggest that CYP2C19 gene might be considered as a novel candidate gene for treatment of cardiovascular disease. The aim of the present study was to evaluate the association between two variants, CYP2C19*2 (681G>A) and CYP2C19*3 (636G>A) and the development of essential hypertension (EH) in Koreans. Materials and Methods: We carried out an association study in a total of 1190 individuals (527 hypertensive subjects and 663 unrelated healthy controls). The CYP2C19 polymorphisms were genotyped using the SNaPShotTM assay. Results: The distribution of alleles and genotypes of CYP2C19*3 showed significant difference between hypertensive patients and normal controls (p=0.011 and p=0.013, respectively). Logistic regression analysis indicated that the CYP2C19*3 (636A) allele carriers were significantly associated with EH [odds ratio, 0.691; 95% confidence interval (CI), 0.512-0.932, p=0.016], in comparison to wild type homozygotes (CYP2C19*1/*1). Neither genotype nor allele distribution of CYP2C19*2 polymorphism showed significant differences between hypertensive and control groups (p>0.05). Conclusion: Our present findings strengthen the evidence of an association between CYP2C19 gene polymorphism and EH prevalence. In particular, the CYP2C19*3 defective allele may contribute to reduced risk for the development of EH.
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참고문헌 (33)
참고문헌 신청
Zhou Q / 2009 / Genetic polymorphism, linkage disequilibrium, haplotype structure and novel allele analysis of CYP2C19 and CYP2D6 in Han Chinese / Pharmacogenomics J 9:380~394
Sinal CJ / 2000 / Targeted disruption of soluble epoxide hydrolase reveals a role in blood pressure regulation / J Biol Chem 275:40504~40510
Laffer CL / 2003 / Differential regulation of natriuresis by 20-hydroxyeicosatetraenoic Acid in human salt-sensitive versus salt-resistant hypertension / Circulation 107:574~578
Zhao X / 2003 / Decreased renal cytochrome P450 2C enzymes and impaired vasodilation are associated with angiotensin salt-sensitive hypertension / Hypertension 41(3 Pt 2):709~714
Ercan B / 2008 / Role of CYP2C9 and CYP2C19 polymorphisms in patients with atherosclerosis / Cell Biochem Funct 26:309~313
Sinal CJ / 2000 / Targeted disruption of soluble epoxide hydrolase reveals a role in blood pressure regulation / J Biol Chem 275:40504~40510
Laffer CL / 2003 / Differential regulation of natriuresis by 20-hydroxyeicosatetraenoic Acid in human salt-sensitive versus salt-resistant hypertension / Circulation 107:574~578
Zhao X / 2003 / Decreased renal cytochrome P450 2C enzymes and impaired vasodilation are associated with angiotensin salt-sensitive hypertension / Hypertension 41(3 Pt 2):709~714
Ercan B / 2008 / Role of CYP2C9 and CYP2C19 polymorphisms in patients with atherosclerosis / Cell Biochem Funct 26:309~313
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