지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
In the present study we evaluated drug-drug interaction potential of ambroxol and cetirizine mediated by inhibition of CYP isoforms including CYP1A2, CYP2A6, CYP2B6, CYP2C9, CYP2C19, CYP2D6, CYP2E1 and CYP3A4 using pooled human liver microsomes (HLMs). As measured by liquid chromatography-electrospray ionization tandem mass spectrometry, cetirizine and ambroxol inhibited significantly CYP2E1 but the maximal inhibition was approximately 36% at 10 ${\mu}M$ cetirizine and 28% at 3 ${\mu}M$ ambroxol. In addition, CYP2D6 activity was decreased to approximately 83% of control activity in pooled HLM incubated with 3 ${\mu}M$ ambroxol. Activities of CYP1A2, CYP2A6, CYP2B6, CYP2C9, CYP2C19, and CYP3A4 were not significantly inhibited by cetirizine and ambroxol. Considering their maximal plasma concentration in human ($C_{max}$ of cetirizine is approximately 0.67 ${\mu}M$ and $C_{max}$ of ambroxol is 0.044 ${\mu}M$), these two drugs have very low possibility in drug-drug interaction by CYP inhibition in clinical situations.
목차
등록된 정보가 없습니다.
참고문헌 (13)
참고문헌 신청
Williams, J. A / 2004 / Drugdrug interactions for UDP-glucuronosyltransferase substrates: a pharmacokinetic explanation for typically observed low exposure (AUCi/AUC) ratios / Drug. Metab. Dispos 32:1201
Guengerich, F. P / 2008 / Cytochrome p450 and chemical toxicology / Chem. Res. Toxicol 21:70
Kim, S. K / 2007 / The role of intracellular signaling in insulin-mediated regulation of drug metabolizing enzyme gene and protein expression / Pharmacol. Ther 11:88
Guengerich, F. P / 1997 / Role of cytochrome P450 enzymes in drug_drug interactions / Adv. Pharmacol 43:7
U.S. Food and drug administration / 2012 / Draft FDA Guidance for Industry, Drug Interaction Studies - Study Design, Data Analysis, Implications for Dosing, and Labeling Recommendations
Guengerich, F. P / 2008 / Cytochrome p450 and chemical toxicology / Chem. Res. Toxicol 21:70
Kim, S. K / 2007 / The role of intracellular signaling in insulin-mediated regulation of drug metabolizing enzyme gene and protein expression / Pharmacol. Ther 11:88
Guengerich, F. P / 1997 / Role of cytochrome P450 enzymes in drug_drug interactions / Adv. Pharmacol 43:7
U.S. Food and drug administration / 2012 / Draft FDA Guidance for Industry, Drug Interaction Studies - Study Design, Data Analysis, Implications for Dosing, and Labeling Recommendations
이 논문의 저자 정보
최근 본 자료
댓글(0)
0