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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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The proteasome plays a major role in the degradation of abnormal proteins within the cell. Therefore, repressed proteasome function is accepted as one of factors contributing the pathogenesis of multiple degenerative diseases. In the present study, we have observed that xanthohumol C, which is one of prenylated flavonoids from hops, increases the expression of the proteasome subunits through the Nrf2 pathway. Treatment of murine renal epithelial TCMK-1 cells with xanthohumol C and its methoxymethoxy-derivative elevated the expression of the Antioxidant Response Element (ARE)-driven reporter gene, as well as Nrf2-target genes including NAD(P)H: quinoneoxidoreductaes 1 (Nqo1). Transcript levels for the catalytic subunits of the proteasome Psmb5 and Psmb6 were increased by these compounds. The activation of the psmb5 promoter by xanthohumol C was abolished when the ARE in this promoter was mutated, indicating that proteasome induction was mediated by the Nrf2-ARE pathway. These results suggest that xanthohumol compounds from hops have a potential benefit on various oxidative stress-associated human diseases through the induction of the proteasome.
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참고문헌 (28)
참고문헌 신청
Itoh, K / 1997 / An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements / Biochem. Biophys. Res.Commun 236:313
Kwak, M. K / 2003 / Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survival / J. Biol. Chem 278:8135
Thimmulappa, R. K / 2002 / Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray / Cancer. Res 62:5196
Kensler, T. W / 2007 / Cell Survival Responses to Environmental Stresses Via the Keap1-Nrf2-ARE Pathway / Annu. Rev. Pharmacol. Toxicol 47:89
Kwak, M. K / 2004 / Chemoprevention through the Keap1-Nrf2 signaling pathway by phase 2 enzyme inducers / Mutat. Res 555:133
Kwak, M. K / 2003 / Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survival / J. Biol. Chem 278:8135
Thimmulappa, R. K / 2002 / Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray / Cancer. Res 62:5196
Kensler, T. W / 2007 / Cell Survival Responses to Environmental Stresses Via the Keap1-Nrf2-ARE Pathway / Annu. Rev. Pharmacol. Toxicol 47:89
Kwak, M. K / 2004 / Chemoprevention through the Keap1-Nrf2 signaling pathway by phase 2 enzyme inducers / Mutat. Res 555:133
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