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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 25 - 31 (7page)
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초록· 키워드
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Inhibition of proteasome activity may reduce many types
of cancer, so it's pathway is effective in cancer as well as in
clinical fields. Here the author has carried out experiment
targeting on the elevation of apoptosis in oral cancer cells by
combination of proteasome inhibitor, lactacystin, and DNA
replication inhibitor, etoposide. The growth of KB cells was
measured by MTT methods and apoptosis was analyzed by
DNA fragmentation and Hochest nucleus staining. The
proteasome activity was analyzed by fluorescent tagged
peptide and cellular protein expression was detected by
Western hybridization. Though lactacystin and etoposide
inhibited KB cell growth alone, but low combined doses
inhibited cell growth more strongly and induced apoptosis.
The proteasome activity was also seriously inhibited by the
combination of both chemicals. Tumor suppressor proteins
and apoptosis inducing proteins were highly increased
under the combination of both chemicals. From above
studies we can conclude that proteasome inhibitors may be
used for the treatment of oral cancer and proteasome
inhibitors with DNA replication inhibitors may be effective
in clinical trials of oral cancer.
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Adachi, N. / 2003 / Hypersensitivity of nonhomologous DNA end-joining mutants to VP-16 and ICRF-193: implications for the repair of topoisomerase IImediated DNA damage / Jour
Adams, J. / 1999 / Proteasome Inhibitors: A Novel Class of Potent and Effective Antitumor Agents / Cancer Research 59 : 2615 ~ 2622
Adams, J. / 2003 / The proteasome: structure, function, and role in the cell / Cancer Treatment Reviews 29 : 3 ~ 9
Aghajanian, C. / 2002 / A phase I trial of the novel proteasome inhibitor PS 341 in advanced solid tumor malignancies / Clinical Cancer Research 8 : 2505 ~ 2511
An, W. G. / 2000 / Protease inhibitor-induced apoptosis: accumulation of wt p53, p21WAF1/CIP1, and induction of apoptosis are independent markers of proteasome inhibition / L
Adams, J. / 1999 / Proteasome Inhibitors: A Novel Class of Potent and Effective Antitumor Agents / Cancer Research 59 : 2615 ~ 2622
Adams, J. / 2003 / The proteasome: structure, function, and role in the cell / Cancer Treatment Reviews 29 : 3 ~ 9
Aghajanian, C. / 2002 / A phase I trial of the novel proteasome inhibitor PS 341 in advanced solid tumor malignancies / Clinical Cancer Research 8 : 2505 ~ 2511
An, W. G. / 2000 / Protease inhibitor-induced apoptosis: accumulation of wt p53, p21WAF1/CIP1, and induction of apoptosis are independent markers of proteasome inhibition / L
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